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• W4376609605 abstract "Abstract In addition to triggering humoral responses, conventional B cells have been described in vitro to cross‐present exogenous antigens activating naïve CD8 + T cells. Nevertheless, the way B cells capture these exogenous antigens and the physiological roles of B cell‐mediated cross‐presentation remain poorly explored. Here, we show that B cells capture bacteria by trans‐phagocytosis from previously infected dendritic cells (DC) when they are in close contact. Bacterial encounter “instructs” the B cells to acquire antigen cross‐presentation abilities, in a process that involves autophagy. Bacteria‐instructed B cells, henceforth referred to as BacB cells, rapidly degrade phagocytosed bacteria, process bacterial antigens and cross‐prime naïve CD8 + T cells which differentiate into specific cytotoxic cells that efficiently control bacterial infections. Moreover, a proof‐of‐concept experiment shows that BacB cells that have captured bacteria expressing tumor antigens could be useful as novel cellular immunotherapies against cancer." @default.
• W4376609605 created "2023-05-17" @default.
• W4376609605 creator A5006841984 @default.
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• W4376609605 creator A5091947691 @default.
• W4376609605 date "2023-05-15" @default.
• W4376609605 modified "2023-10-18" @default.
• W4376609605 title "Bacteria‐instructed B cells cross‐prime naïve <scp>CD8</scp>⁺ T cells triggering effective cytotoxic responses" @default.
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