Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376609662> ?p ?o ?g. }
- W4376609662 endingPage "391" @default.
- W4376609662 startingPage "383" @default.
- W4376609662 abstract "We applied 7 Tesla phase sensitive imaging to evaluate the impact of brain iron levels on depression severity and cognitive function in individuals with major depressive disorder (MDD) treated with mindfulness-based cognitive therapy (MBCT). Seventeen unmedicated MDD participants underwent MRI, evaluation of depression severity, and cognitive testing before and after receiving MBCT, compared to fourteen healthy controls (HC). Local field shift (LFS) values, measures of brain iron levels, were derived from phase images in the putamen, caudate, globus pallidus (GP), anterior cingulate cortex (ACC) and thalamus. Compared to the HC group, the MDD group had significantly lower baseline LFS (indicative of higher iron) in the left GP and left putamen and had a higher number of subjects with impairment in a test of information processing speed. In the MDD group, lower LFS values in the left and right ACC, right putamen, right GP, and right thalamus were significantly associated with depression severity; and lower LFS in the right GP was correlated with worse performance on measures of attention. All MBCT participants experienced depression relief. MBCT treatment also significantly improved executive function and attention. MBCT participants with lower baseline LFS values in the right caudate experienced significantly greater improvement in depression severity with treatment; and those with lower LFS values in the right ACC, right caudate, and right GB at baseline performed better on measures of verbal learning and memory after MBCT. Our study highlights the potential contribution of subtle differences in brain iron to MDD symptoms and their successful treatment." @default.
- W4376609662 created "2023-05-17" @default.
- W4376609662 creator A5006662760 @default.
- W4376609662 creator A5011690840 @default.
- W4376609662 creator A5018158005 @default.
- W4376609662 creator A5021061834 @default.
- W4376609662 creator A5025824857 @default.
- W4376609662 creator A5026977235 @default.
- W4376609662 creator A5030100878 @default.
- W4376609662 creator A5035862378 @default.
- W4376609662 creator A5039683031 @default.
- W4376609662 creator A5058075739 @default.
- W4376609662 creator A5063053695 @default.
- W4376609662 creator A5078128075 @default.
- W4376609662 date "2023-08-01" @default.
- W4376609662 modified "2023-10-18" @default.
- W4376609662 title "Evaluation of major depressive disorder using 7 Tesla phase sensitive neuroimaging before and after mindfulness-based cognitive therapy" @default.
- W4376609662 cites W1975535890 @default.
- W4376609662 cites W1991085741 @default.
- W4376609662 cites W1997183854 @default.
- W4376609662 cites W2020778970 @default.
- W4376609662 cites W2028003028 @default.
- W4376609662 cites W2049201244 @default.
- W4376609662 cites W2075272565 @default.
- W4376609662 cites W2095980807 @default.
- W4376609662 cites W2096745312 @default.
- W4376609662 cites W2108891761 @default.
- W4376609662 cites W2134376379 @default.
- W4376609662 cites W2162056840 @default.
- W4376609662 cites W2163159982 @default.
- W4376609662 cites W2264135922 @default.
- W4376609662 cites W2560553695 @default.
- W4376609662 cites W2564770969 @default.
- W4376609662 cites W2568027254 @default.
- W4376609662 cites W2591408616 @default.
- W4376609662 cites W2593249572 @default.
- W4376609662 cites W2606576077 @default.
- W4376609662 cites W2733471510 @default.
- W4376609662 cites W2749527858 @default.
- W4376609662 cites W2751884637 @default.
- W4376609662 cites W2783729637 @default.
- W4376609662 cites W2801536852 @default.
- W4376609662 cites W2803952783 @default.
- W4376609662 cites W2809229523 @default.
- W4376609662 cites W2886227394 @default.
- W4376609662 cites W2901954088 @default.
- W4376609662 cites W2969617477 @default.
- W4376609662 cites W2970408478 @default.
- W4376609662 cites W2980920653 @default.
- W4376609662 cites W2991126028 @default.
- W4376609662 cites W3002519818 @default.
- W4376609662 cites W3110117871 @default.
- W4376609662 cites W3197209860 @default.
- W4376609662 cites W3197698931 @default.
- W4376609662 cites W3199636520 @default.
- W4376609662 doi "https://doi.org/10.1016/j.jad.2023.05.038" @default.
- W4376609662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37192691" @default.
- W4376609662 hasPublicationYear "2023" @default.
- W4376609662 type Work @default.
- W4376609662 citedByCount "0" @default.
- W4376609662 crossrefType "journal-article" @default.
- W4376609662 hasAuthorship W4376609662A5006662760 @default.
- W4376609662 hasAuthorship W4376609662A5011690840 @default.
- W4376609662 hasAuthorship W4376609662A5018158005 @default.
- W4376609662 hasAuthorship W4376609662A5021061834 @default.
- W4376609662 hasAuthorship W4376609662A5025824857 @default.
- W4376609662 hasAuthorship W4376609662A5026977235 @default.
- W4376609662 hasAuthorship W4376609662A5030100878 @default.
- W4376609662 hasAuthorship W4376609662A5035862378 @default.
- W4376609662 hasAuthorship W4376609662A5039683031 @default.
- W4376609662 hasAuthorship W4376609662A5058075739 @default.
- W4376609662 hasAuthorship W4376609662A5063053695 @default.
- W4376609662 hasAuthorship W4376609662A5078128075 @default.
- W4376609662 hasBestOaLocation W43766096621 @default.
- W4376609662 hasConcept C118552586 @default.
- W4376609662 hasConcept C126322002 @default.
- W4376609662 hasConcept C139719470 @default.
- W4376609662 hasConcept C15744967 @default.
- W4376609662 hasConcept C162324750 @default.
- W4376609662 hasConcept C169760540 @default.
- W4376609662 hasConcept C169900460 @default.
- W4376609662 hasConcept C2776867660 @default.
- W4376609662 hasConcept C2777808739 @default.
- W4376609662 hasConcept C2778402161 @default.
- W4376609662 hasConcept C2779246727 @default.
- W4376609662 hasConcept C2779477915 @default.
- W4376609662 hasConcept C2779714222 @default.
- W4376609662 hasConcept C2780051608 @default.
- W4376609662 hasConcept C2780444219 @default.
- W4376609662 hasConcept C2781423529 @default.
- W4376609662 hasConcept C58693492 @default.
- W4376609662 hasConcept C70410870 @default.
- W4376609662 hasConcept C71924100 @default.
- W4376609662 hasConceptScore W4376609662C118552586 @default.
- W4376609662 hasConceptScore W4376609662C126322002 @default.
- W4376609662 hasConceptScore W4376609662C139719470 @default.
- W4376609662 hasConceptScore W4376609662C15744967 @default.
- W4376609662 hasConceptScore W4376609662C162324750 @default.