Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376609780> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4376609780 abstract "Abstract The skin is the main route of exposure to plant protection products for operators, workers, residents, and bystanders. Assessing dermal absorption is key for evaluating pesticide exposure risks. However, conducting in vitro dermal absorption studies using human skin is resource-intensive. Therefore, establishing realistic regulatory default values is essential for non-dietary risk assessment and ensuring safety. This project analysed 468 in vitro dermal absorption studies with human skin compiled by ProHuma. Combined with a prior database by Aggarwal et al. (2015), the dataset comprised 759 GLP-compliant studies covering 25 formulation types and 248 active substances at various concentrations. The assessment confirmed earlier findings that dermal absorption shows no correlation with molecular weight or log Pow and does not increase linearly with dilution. Based on the comprehensive ProHuma/ECPA dataset, dermal absorption default values are proposed: 2% for solid concentrates, 5% for liquid concentrates, 30% for solid dilutions, and 34% for liquid dilutions. These values, derived conservatively using the 95th percentile, better represent formulations and agricultural use cases, reducing the need for unnecessary studies. The project also suggests read-across between different formulation types. By proposing more realistic default values and read-across approaches, it streamlines decision-making and supports safety in agriculture." @default.
- W4376609780 created "2023-05-17" @default.
- W4376609780 creator A5008944199 @default.
- W4376609780 creator A5015463175 @default.
- W4376609780 creator A5026769299 @default.
- W4376609780 creator A5032601808 @default.
- W4376609780 creator A5037650960 @default.
- W4376609780 creator A5064648372 @default.
- W4376609780 creator A5069646032 @default.
- W4376609780 creator A5091947732 @default.
- W4376609780 creator A5091947733 @default.
- W4376609780 creator A5091947734 @default.
- W4376609780 creator A5091947735 @default.
- W4376609780 creator A5091947736 @default.
- W4376609780 date "2023-05-14" @default.
- W4376609780 modified "2023-09-27" @default.
- W4376609780 title "Default Values And Read-Across Proposal For Dermal Absorption Based On Human Skin In Vitro Studies Dataset With Pesticides" @default.
- W4376609780 cites W2016056010 @default.
- W4376609780 doi "https://doi.org/10.1101/2023.05.11.540395" @default.
- W4376609780 hasPublicationYear "2023" @default.
- W4376609780 type Work @default.
- W4376609780 citedByCount "0" @default.
- W4376609780 crossrefType "posted-content" @default.
- W4376609780 hasAuthorship W4376609780A5008944199 @default.
- W4376609780 hasAuthorship W4376609780A5015463175 @default.
- W4376609780 hasAuthorship W4376609780A5026769299 @default.
- W4376609780 hasAuthorship W4376609780A5032601808 @default.
- W4376609780 hasAuthorship W4376609780A5037650960 @default.
- W4376609780 hasAuthorship W4376609780A5064648372 @default.
- W4376609780 hasAuthorship W4376609780A5069646032 @default.
- W4376609780 hasAuthorship W4376609780A5091947732 @default.
- W4376609780 hasAuthorship W4376609780A5091947733 @default.
- W4376609780 hasAuthorship W4376609780A5091947734 @default.
- W4376609780 hasAuthorship W4376609780A5091947735 @default.
- W4376609780 hasAuthorship W4376609780A5091947736 @default.
- W4376609780 hasBestOaLocation W43766097801 @default.
- W4376609780 hasConcept C121332964 @default.
- W4376609780 hasConcept C125287762 @default.
- W4376609780 hasConcept C142724271 @default.
- W4376609780 hasConcept C159985019 @default.
- W4376609780 hasConcept C161176658 @default.
- W4376609780 hasConcept C184112429 @default.
- W4376609780 hasConcept C18903297 @default.
- W4376609780 hasConcept C192562407 @default.
- W4376609780 hasConcept C204787440 @default.
- W4376609780 hasConcept C2777459323 @default.
- W4376609780 hasConcept C33070731 @default.
- W4376609780 hasConcept C39432304 @default.
- W4376609780 hasConcept C41008148 @default.
- W4376609780 hasConcept C54355233 @default.
- W4376609780 hasConcept C71924100 @default.
- W4376609780 hasConcept C86803240 @default.
- W4376609780 hasConcept C96618451 @default.
- W4376609780 hasConcept C97355855 @default.
- W4376609780 hasConceptScore W4376609780C121332964 @default.
- W4376609780 hasConceptScore W4376609780C125287762 @default.
- W4376609780 hasConceptScore W4376609780C142724271 @default.
- W4376609780 hasConceptScore W4376609780C159985019 @default.
- W4376609780 hasConceptScore W4376609780C161176658 @default.
- W4376609780 hasConceptScore W4376609780C184112429 @default.
- W4376609780 hasConceptScore W4376609780C18903297 @default.
- W4376609780 hasConceptScore W4376609780C192562407 @default.
- W4376609780 hasConceptScore W4376609780C204787440 @default.
- W4376609780 hasConceptScore W4376609780C2777459323 @default.
- W4376609780 hasConceptScore W4376609780C33070731 @default.
- W4376609780 hasConceptScore W4376609780C39432304 @default.
- W4376609780 hasConceptScore W4376609780C41008148 @default.
- W4376609780 hasConceptScore W4376609780C54355233 @default.
- W4376609780 hasConceptScore W4376609780C71924100 @default.
- W4376609780 hasConceptScore W4376609780C86803240 @default.
- W4376609780 hasConceptScore W4376609780C96618451 @default.
- W4376609780 hasConceptScore W4376609780C97355855 @default.
- W4376609780 hasLocation W43766097801 @default.
- W4376609780 hasOpenAccess W4376609780 @default.
- W4376609780 hasPrimaryLocation W43766097801 @default.
- W4376609780 hasRelatedWork W132084387 @default.
- W4376609780 hasRelatedWork W2046455648 @default.
- W4376609780 hasRelatedWork W2337367379 @default.
- W4376609780 hasRelatedWork W2367935032 @default.
- W4376609780 hasRelatedWork W2386303359 @default.
- W4376609780 hasRelatedWork W2390019697 @default.
- W4376609780 hasRelatedWork W2899084033 @default.
- W4376609780 hasRelatedWork W2901150885 @default.
- W4376609780 hasRelatedWork W3119374807 @default.
- W4376609780 hasRelatedWork W4206023984 @default.
- W4376609780 isParatext "false" @default.
- W4376609780 isRetracted "false" @default.
- W4376609780 workType "article" @default.