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- W4376609834 abstract "Abstract Amdoparvoviruses infect various carnivores, including mustelids, canids and felids et al. Aleutian mink disease virus (AMDV), Carnivore amdoparvovirus 1 , infects mink and other Mustelidae and causes subclinical diseases or fatal chronic immune stimulation and immune complex diseases. Here, we identified a nearly complete genome (4265nt) of a novel amdoparvovirus from farmed Asian badgers ( Meles meles ) and tentatively named Meles meles amdoparvovirus (MMAV). Furthermore, we constructed phylogenetic trees based on the NS1 and VP2 proteins, respectively, as well as the amdoparvoviral VP2 nucleotide hypervariable region. MMAV NS1 protein shared 62.6%-88.8% sequence identities with other known amdoparvoviruses and phylogenetically clustered into a unique clade, while VP2 protein shared 76.7%-97.2% identities and clustered into two clades, of which one was more closely related to raccoon dog and arctic fox amdoparvovirus (RFAV), and the other clade is independent of other known amdoparvoviruses. According to the NS1 genetic distance-based criteria, MMAV is classified as a novel species of Amdoparvovirus. the positive rate for amdoparvovirus by PCR was 32.8% (47/143) in 143 clinical samples collected from 134 individual badgers. MMAV DNA was detected in feces, blood, spleen, liver, lung, and adipose tissue from Asian badgers. Eight isolates were sequenced from eight samples, with five obtaining approximate complete genomes. Six serum samples were PCR,CIEP and IAT-positive, with four having high serum antibody titers (＞512) against AMDV-G. Twenty-six of the 41 amdoparvovirus-positive badgers exhibited diseased symptoms, and some necropsy revealed organic lesions. Therefore, these lines of evidence suggested that we discovered novel and diverse amdoparvoviruses, MMAVs, that naturally infect Asian badgers of mustelid and may be cause Aleutian disease in badgers similar to that seen in mink. Furthermore, our findings supported that mustelid species are susceptible to diverse amdoparvoviruses and the molecular characteristics of amdoparvorviruses divergence between hosts species." @default.
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- W4376609834 date "2023-05-15" @default.
- W4376609834 modified "2023-10-03" @default.
- W4376609834 title "Diverse Amdoparvoviruses Infecting Farmed Asian Badgers (Meles meles)" @default.
- W4376609834 doi "https://doi.org/10.21203/rs.3.rs-2679567/v1" @default.
- W4376609834 hasPublicationYear "2023" @default.
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