Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376612828> ?p ?o ?g. }
- W4376612828 endingPage "3072" @default.
- W4376612828 startingPage "3054" @default.
- W4376612828 abstract "Crohn's disease (CD) is an inflammatory bowel disease (IBD) with complex clinical manifestations such as chronic diarrhea, weight loss and hematochezia. Despite the increasing incidence worldwide, cure of CD remains extremely difficult. The rapid development of high-throughput sequencing technology with integrated-omics analyses in recent years has provided a new means for exploring the pathogenesis, mining the biomarkers and designing targeted personalized therapeutics of CD. Host genomics and epigenomics unveil heredity-related mechanisms of susceptible individuals, while microbiome and metabolomics map host-microbe interactions in CD patients. Proteomics shows great potential in searching for promising biomarkers. Nonetheless, single omics technology cannot holistically connect the mechanisms with heterogeneity of pathological behavior in CD. The rise of multi-omics analysis integrates genetic/epigenetic profiles with protein/microbial metabolite functionality, providing new hope for comprehensive and in-depth exploration of CD. Herein, we emphasized the different omics features and applications of CD and discussed the current research and limitations of multi-omics in CD. This review will update and deepen our understanding of CD from integration of broad omics spectra and will provide new evidence for targeted individualized therapeutics." @default.
- W4376612828 created "2023-05-17" @default.
- W4376612828 creator A5001971782 @default.
- W4376612828 creator A5014860311 @default.
- W4376612828 creator A5016302401 @default.
- W4376612828 creator A5016487777 @default.
- W4376612828 creator A5038032242 @default.
- W4376612828 creator A5039778333 @default.
- W4376612828 creator A5049490875 @default.
- W4376612828 creator A5067652312 @default.
- W4376612828 creator A5084993733 @default.
- W4376612828 creator A5085353674 @default.
- W4376612828 date "2023-01-01" @default.
- W4376612828 modified "2023-10-15" @default.
- W4376612828 title "Multi-omics in Crohn's disease: New insights from inside" @default.
- W4376612828 cites W1014257459 @default.
- W4376612828 cites W1517046324 @default.
- W4376612828 cites W1534317053 @default.
- W4376612828 cites W1546737260 @default.
- W4376612828 cites W1547943993 @default.
- W4376612828 cites W1599664643 @default.
- W4376612828 cites W1670573097 @default.
- W4376612828 cites W1732275446 @default.
- W4376612828 cites W1832079889 @default.
- W4376612828 cites W1927464939 @default.
- W4376612828 cites W1938958129 @default.
- W4376612828 cites W1986386190 @default.
- W4376612828 cites W2009258758 @default.
- W4376612828 cites W2010593845 @default.
- W4376612828 cites W2011061591 @default.
- W4376612828 cites W2011444679 @default.
- W4376612828 cites W2015150982 @default.
- W4376612828 cites W2034975193 @default.
- W4376612828 cites W2047208232 @default.
- W4376612828 cites W2050587894 @default.
- W4376612828 cites W2056978288 @default.
- W4376612828 cites W2060748779 @default.
- W4376612828 cites W2062222093 @default.
- W4376612828 cites W2063380767 @default.
- W4376612828 cites W2067567596 @default.
- W4376612828 cites W2071273298 @default.
- W4376612828 cites W2071882066 @default.
- W4376612828 cites W2074791309 @default.
- W4376612828 cites W2079843936 @default.
- W4376612828 cites W2081471671 @default.
- W4376612828 cites W2085284704 @default.
- W4376612828 cites W2090201519 @default.
- W4376612828 cites W2096576371 @default.
- W4376612828 cites W2096701144 @default.
- W4376612828 cites W2097804645 @default.
- W4376612828 cites W2102424853 @default.
- W4376612828 cites W2104423086 @default.
- W4376612828 cites W2106779017 @default.
- W4376612828 cites W2110758916 @default.
- W4376612828 cites W2118822739 @default.
- W4376612828 cites W2121259978 @default.
- W4376612828 cites W2127465048 @default.
- W4376612828 cites W2133371096 @default.
- W4376612828 cites W2143625465 @default.
- W4376612828 cites W2152751713 @default.
- W4376612828 cites W2155860422 @default.
- W4376612828 cites W2158132545 @default.
- W4376612828 cites W2159612774 @default.
- W4376612828 cites W2160855953 @default.
- W4376612828 cites W2164027931 @default.
- W4376612828 cites W2172187177 @default.
- W4376612828 cites W2186106699 @default.
- W4376612828 cites W2221142629 @default.
- W4376612828 cites W2262277611 @default.
- W4376612828 cites W2269254929 @default.
- W4376612828 cites W2297994856 @default.
- W4376612828 cites W2312839949 @default.
- W4376612828 cites W2328393125 @default.
- W4376612828 cites W2403020807 @default.
- W4376612828 cites W2404718883 @default.
- W4376612828 cites W2428595929 @default.
- W4376612828 cites W2491590722 @default.
- W4376612828 cites W2528109221 @default.
- W4376612828 cites W2545115658 @default.
- W4376612828 cites W2551464444 @default.
- W4376612828 cites W2570178861 @default.
- W4376612828 cites W2581896965 @default.
- W4376612828 cites W2586374101 @default.
- W4376612828 cites W2586959160 @default.
- W4376612828 cites W2593695507 @default.
- W4376612828 cites W2599259446 @default.
- W4376612828 cites W2724938313 @default.
- W4376612828 cites W2733896597 @default.
- W4376612828 cites W2736839127 @default.
- W4376612828 cites W2745643218 @default.
- W4376612828 cites W2746163443 @default.
- W4376612828 cites W2746234678 @default.
- W4376612828 cites W2748192442 @default.
- W4376612828 cites W2754579667 @default.
- W4376612828 cites W2762548631 @default.
- W4376612828 cites W2762883136 @default.
- W4376612828 cites W2766046358 @default.
- W4376612828 cites W2770092353 @default.