FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376613585> ?p ?o ?g. }

• W4376613585 endingPage "101296" @default.
• W4376613585 startingPage "101296" @default.
• W4376613585 abstract "We recently reported that high cancer cell protein levels of PD-L2 in patients (pts) with treatment-naïve estrogen receptor-positive breast cancer (ER+ BC), was an independent predictor of shorter progression-free survival in two distinct cohort of pts (1). These findings suggest that PD-L2 may help improve BC pt selection for PD-1 inhibitors. We therefore initiated efforts to determine baseline expression patterns of PD-L1 and PD-L2 in BC. PD-L1 and PD-L2 protein levels in cancer cells and tumor-infiltrating immune cells were prospectively analyzed by immunohistochemistry (IHC) using validated antibodies in diagnostic core biopsies of 28 consecutive pts diagnosed with localized or locoregional ER+/HER2- BC or TNBC. Percent positivity of PD-L1 and PD-L2 in cancer cells and immune cells was determined by a breast pathologist. PD-L1 and PD-L2 expression patterns in BC differed in several ways. First, PD-L1-positivity in immune cells was higher than in cancer cells (median=5.0% vs. 0.05%; p=0.002), whereas PD-L2-positivity was higher in cancer vs. immune cells (median=20% vs. 5.0%; p=0.001). Second, there was no significant correlation between PD-L1 and PD-L2 expression, neither across all cases (N=28), nor within ER+ (N=20) or TNBC (N=8) cases. Third, PD-L1 positivity in cancer cells and immune cells were positively correlated in TNBC (rho=0.72, p=0.045) but not in ER+ BC. Conversely, PD-L2 positivity was positively correlated in ER+ BC (rho=0.62, p=0.004) but not in TNBC. TNBC diverged from ER+ BC by displaying higher PD-L1 positivity in immune cells (median=20.0% vs. 1.0%; p=0.004). By the conventional cutpoint for positivity of ≥1% for PD-L1 and PD-L2 in cancer cells or immune cells, all TNBC tumors were PD-L1-positive (8/8), with 7 also being PD-L2-positive. Of the 20 ER+ cases, 15 were PD-L2-positive, of which only 8 were also PD-L1-positive. PD-L1 and PD-L2 proteins show divergent expression and are not correlated in BC. Discordant PD-L2 and PD-L1 expression may be more common in ER+ BC than in TNBC. This progress justifies efforts to explore PD-L2 as a complementary marker to PD-L1 for improved prediction of responses to PD-1 inhibitors, which may also benefit pts with aggressive ER+ BC. Reference: 1.JCO Precis Oncol 7:e2100498, 2023." @default.
• W4376613585 created "2023-05-17" @default.
• W4376613585 creator A5001198756 @default.
• W4376613585 creator A5005569085 @default.
• W4376613585 creator A5016607803 @default.
• W4376613585 creator A5022471130 @default.
• W4376613585 creator A5035142704 @default.
• W4376613585 creator A5035890697 @default.
• W4376613585 creator A5058220968 @default.
• W4376613585 creator A5058435503 @default.
• W4376613585 creator A5062114840 @default.
• W4376613585 creator A5065798455 @default.
• W4376613585 creator A5075046330 @default.
• W4376613585 creator A5086053207 @default.
• W4376613585 date "2023-05-01" @default.
• W4376613585 modified "2023-10-16" @default.
• W4376613585 title "73P Frequent discordance in PD-L1 and PD-L2 protein expression in breast cancer" @default.
• W4376613585 doi "https://doi.org/10.1016/j.esmoop.2023.101296" @default.
• W4376613585 hasPublicationYear "2023" @default.
• W4376613585 type Work @default.
• W4376613585 citedByCount "0" @default.
• W4376613585 crossrefType "journal-article" @default.
• W4376613585 hasAuthorship W4376613585A5001198756 @default.
• W4376613585 hasAuthorship W4376613585A5005569085 @default.
• W4376613585 hasAuthorship W4376613585A5016607803 @default.
• W4376613585 hasAuthorship W4376613585A5022471130 @default.
• W4376613585 hasAuthorship W4376613585A5035142704 @default.
• W4376613585 hasAuthorship W4376613585A5035890697 @default.
• W4376613585 hasAuthorship W4376613585A5058220968 @default.
• W4376613585 hasAuthorship W4376613585A5058435503 @default.
• W4376613585 hasAuthorship W4376613585A5062114840 @default.
• W4376613585 hasAuthorship W4376613585A5065798455 @default.
• W4376613585 hasAuthorship W4376613585A5075046330 @default.
• W4376613585 hasAuthorship W4376613585A5086053207 @default.
• W4376613585 hasBestOaLocation W43766135851 @default.
• W4376613585 hasConcept C121608353 @default.
• W4376613585 hasConcept C126322002 @default.
• W4376613585 hasConcept C143998085 @default.
• W4376613585 hasConcept C159654299 @default.
• W4376613585 hasConcept C203014093 @default.
• W4376613585 hasConcept C204232928 @default.
• W4376613585 hasConcept C2777701055 @default.
• W4376613585 hasConcept C2778326572 @default.
• W4376613585 hasConcept C2781053074 @default.
• W4376613585 hasConcept C502942594 @default.
• W4376613585 hasConcept C530470458 @default.
• W4376613585 hasConcept C71924100 @default.
• W4376613585 hasConcept C84606932 @default.
• W4376613585 hasConcept C8891405 @default.
• W4376613585 hasConcept C96232424 @default.
• W4376613585 hasConceptScore W4376613585C121608353 @default.
• W4376613585 hasConceptScore W4376613585C126322002 @default.
• W4376613585 hasConceptScore W4376613585C143998085 @default.
• W4376613585 hasConceptScore W4376613585C159654299 @default.
• W4376613585 hasConceptScore W4376613585C203014093 @default.
• W4376613585 hasConceptScore W4376613585C204232928 @default.
• W4376613585 hasConceptScore W4376613585C2777701055 @default.
• W4376613585 hasConceptScore W4376613585C2778326572 @default.
• W4376613585 hasConceptScore W4376613585C2781053074 @default.
• W4376613585 hasConceptScore W4376613585C502942594 @default.
• W4376613585 hasConceptScore W4376613585C530470458 @default.
• W4376613585 hasConceptScore W4376613585C71924100 @default.
• W4376613585 hasConceptScore W4376613585C84606932 @default.
• W4376613585 hasConceptScore W4376613585C8891405 @default.
• W4376613585 hasConceptScore W4376613585C96232424 @default.
• W4376613585 hasIssue "1" @default.
• W4376613585 hasLocation W43766135851 @default.
• W4376613585 hasOpenAccess W4376613585 @default.
• W4376613585 hasPrimaryLocation W43766135851 @default.
• W4376613585 hasRelatedWork W1970614368 @default.
• W4376613585 hasRelatedWork W2224319365 @default.
• W4376613585 hasRelatedWork W2352033025 @default.
• W4376613585 hasRelatedWork W2651034595 @default.
• W4376613585 hasRelatedWork W2765336906 @default.
• W4376613585 hasRelatedWork W2894907676 @default.
• W4376613585 hasRelatedWork W3109088106 @default.
• W4376613585 hasRelatedWork W317834158 @default.
• W4376613585 hasRelatedWork W4283731173 @default.
• W4376613585 hasRelatedWork W4291367166 @default.
• W4376613585 hasVolume "8" @default.
• W4376613585 isParatext "false" @default.
• W4376613585 isRetracted "false" @default.
• W4376613585 workType "article" @default.