Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376613768> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4376613768 endingPage "101358" @default.
- W4376613768 startingPage "101358" @default.
- W4376613768 abstract "Breast cancer (BC) is the most commonly diagnosed cancer and the second cause of cancer-specific death in women worldwide. Increasing evidence suggests that gut microbial dysbiosis may have a role to play in the pathogenesis, treatment and prognosis of BC. The “BiotaCancerSurvivors” was a prospective, longitudinal, observational, unicentric and case-control study that aimed to analyse whether the gut microbiota differs between cancer survivors and a database of healthy controls. In this first analysis, samples from 23 BC survivors (group 1) and 291 healthy female controls (group 2) were characterised through the V3 and V4 regions that encode the “16S rRNA” gene of each bacteria. The samples were sequenced by Next Generation Sequencing (NGS), and the taxonomy was identified by resorting to Kraken2 and improved with Bracken, using a curated database called 'GutHealth_DB'. The α and β-diversity analyses were used to determine the gut microbiota's richness and evenness. Mann-Whitney U test was applied to assess differential abundance between both groups. Firmicutes/Bacteroidetes ratio was calculated using Kruskal-Wallis chi-squared test. The α-diversity was significantly higher in group 1 (p=.28e-12 for the Chao index and p= 1.64e-12 for the ACE index). Shannon index wasn't statistically different between the two groups (p=.72). The microbiota composition was different between both groups: a null hypothesis was rejected for PERMANOVA (p=9.99e-05) and Anosim (p=.04) and was not rejected for β-dispersion (p=.158), using Unifrac weighted distance. Relative abundance of 14 phyla, 29 classes, 25 orders, 64 families, 116 genera and 74 species differed significantly between both groups. F/B ratio was signicantly lower in group 1 than in group 2, p<0.001. We observed significant taxonomic disparities between BC survivors and healthy controls. Additional studies are needed to clarify the involved mechanisms and explore the relationship between microbiota and BC survivorship. Still, the data we possess so far, instills a need for further exploration of this field, given the potential microbiota role as a prognostic biomarker for BC survivorship." @default.
- W4376613768 created "2023-05-17" @default.
- W4376613768 creator A5009959997 @default.
- W4376613768 creator A5014087839 @default.
- W4376613768 creator A5015170004 @default.
- W4376613768 creator A5023103564 @default.
- W4376613768 creator A5035505377 @default.
- W4376613768 creator A5056024762 @default.
- W4376613768 creator A5059309903 @default.
- W4376613768 creator A5063556091 @default.
- W4376613768 creator A5070067082 @default.
- W4376613768 creator A5089434574 @default.
- W4376613768 date "2023-05-01" @default.
- W4376613768 modified "2023-09-27" @default.
- W4376613768 title "262P Breast cancer survivors and healthy women: Could gut microbiota make a difference? “BiotaCancerSurvivors”: A case-control study" @default.
- W4376613768 doi "https://doi.org/10.1016/j.esmoop.2023.101358" @default.
- W4376613768 hasPublicationYear "2023" @default.
- W4376613768 type Work @default.
- W4376613768 citedByCount "0" @default.
- W4376613768 crossrefType "journal-article" @default.
- W4376613768 hasAuthorship W4376613768A5009959997 @default.
- W4376613768 hasAuthorship W4376613768A5014087839 @default.
- W4376613768 hasAuthorship W4376613768A5015170004 @default.
- W4376613768 hasAuthorship W4376613768A5023103564 @default.
- W4376613768 hasAuthorship W4376613768A5035505377 @default.
- W4376613768 hasAuthorship W4376613768A5056024762 @default.
- W4376613768 hasAuthorship W4376613768A5059309903 @default.
- W4376613768 hasAuthorship W4376613768A5063556091 @default.
- W4376613768 hasAuthorship W4376613768A5070067082 @default.
- W4376613768 hasAuthorship W4376613768A5089434574 @default.
- W4376613768 hasBestOaLocation W43766137681 @default.
- W4376613768 hasConcept C121608353 @default.
- W4376613768 hasConcept C126322002 @default.
- W4376613768 hasConcept C151437367 @default.
- W4376613768 hasConcept C18903297 @default.
- W4376613768 hasConcept C203014093 @default.
- W4376613768 hasConcept C2777165150 @default.
- W4376613768 hasConcept C2777385719 @default.
- W4376613768 hasConcept C2777695942 @default.
- W4376613768 hasConcept C30968088 @default.
- W4376613768 hasConcept C42062724 @default.
- W4376613768 hasConcept C42407357 @default.
- W4376613768 hasConcept C523546767 @default.
- W4376613768 hasConcept C530470458 @default.
- W4376613768 hasConcept C53565203 @default.
- W4376613768 hasConcept C539455810 @default.
- W4376613768 hasConcept C54355233 @default.
- W4376613768 hasConcept C71924100 @default.
- W4376613768 hasConcept C86803240 @default.
- W4376613768 hasConcept C90856448 @default.
- W4376613768 hasConceptScore W4376613768C121608353 @default.
- W4376613768 hasConceptScore W4376613768C126322002 @default.
- W4376613768 hasConceptScore W4376613768C151437367 @default.
- W4376613768 hasConceptScore W4376613768C18903297 @default.
- W4376613768 hasConceptScore W4376613768C203014093 @default.
- W4376613768 hasConceptScore W4376613768C2777165150 @default.
- W4376613768 hasConceptScore W4376613768C2777385719 @default.
- W4376613768 hasConceptScore W4376613768C2777695942 @default.
- W4376613768 hasConceptScore W4376613768C30968088 @default.
- W4376613768 hasConceptScore W4376613768C42062724 @default.
- W4376613768 hasConceptScore W4376613768C42407357 @default.
- W4376613768 hasConceptScore W4376613768C523546767 @default.
- W4376613768 hasConceptScore W4376613768C530470458 @default.
- W4376613768 hasConceptScore W4376613768C53565203 @default.
- W4376613768 hasConceptScore W4376613768C539455810 @default.
- W4376613768 hasConceptScore W4376613768C54355233 @default.
- W4376613768 hasConceptScore W4376613768C71924100 @default.
- W4376613768 hasConceptScore W4376613768C86803240 @default.
- W4376613768 hasConceptScore W4376613768C90856448 @default.
- W4376613768 hasIssue "1" @default.
- W4376613768 hasLocation W43766137681 @default.
- W4376613768 hasOpenAccess W4376613768 @default.
- W4376613768 hasPrimaryLocation W43766137681 @default.
- W4376613768 hasRelatedWork W2012289680 @default.
- W4376613768 hasRelatedWork W2136344314 @default.
- W4376613768 hasRelatedWork W2467184611 @default.
- W4376613768 hasRelatedWork W2492067870 @default.
- W4376613768 hasRelatedWork W2971708521 @default.
- W4376613768 hasRelatedWork W3016396428 @default.
- W4376613768 hasRelatedWork W4223497657 @default.
- W4376613768 hasRelatedWork W4282827724 @default.
- W4376613768 hasRelatedWork W4310598025 @default.
- W4376613768 hasRelatedWork W4378746547 @default.
- W4376613768 hasVolume "8" @default.
- W4376613768 isParatext "false" @default.
- W4376613768 isRetracted "false" @default.
- W4376613768 workType "article" @default.