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• W4376614491 abstract "Protein A chromatography is ubiquitous to antibody purification. The high specificity of Protein A for binding the Fc-region of antibodies and related products enables unmatched clearance of process impurities like host cell proteins, DNA, and virus particles. A recent development is the commercialization of research-scale Protein A membrane chromatography products that can perform capture step purification with short residence times (RT) on the order of seconds. This study investigates process-relevant performance and physical properties of four Protein A membranes: Purilogics Purexa™ PrA, Gore® Protein Capture Device, Cytiva HiTrap™ Fibro PrismA, and Sartorius Sartobind® Protein A. Performance metrics include dynamic binding capacity, equilibrium binding capacity, regeneration-reuse, impurity clearance, and elution volumes. Physical properties include permeability, pore diameter, specific surface area, and dead volume. Key results indicate that all membranes except the Gore® Protein Capture Device operate with flow rate-independent binding capacities; the Purilogics Purexa™ PrA and Cytiva HiTrap Fibro™ PrismA have binding capacities on par with resins, with orders of magnitude faster throughput; and dead volume and hydrodynamics play major roles in elution behavior. Results from this study will enable bioprocess scientists to understand the ways that Protein A membranes can fit into their antibody process development strategies." @default.
• W4376614491 created "2023-05-17" @default.
• W4376614491 creator A5028571067 @default.
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• W4376614491 date "2023-05-12" @default.
• W4376614491 modified "2023-10-11" @default.
• W4376614491 title "Comparative Evaluation of Commercial Protein A Membranes for the Rapid Purification of Antibodies" @default.
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• W4376614491 doi "https://doi.org/10.3390/membranes13050511" @default.
• W4376614491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37233572" @default.
• W4376614491 hasPublicationYear "2023" @default.
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