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• W4376630272 abstract "Depression is highly prevalent (6% 1-year prevalence) and is the second leading cause of disability worldwide. Available treatment options for depression are far from optimal, with response rates only around 50%. This is most likely related to a heterogeneous clinical presentation of major depression disorder (MDD), suggesting different manifestations of underlying pathophysiological mechanisms. Poorer treatment outcomes to first-line antidepressants were reported in MDD patients endorsing an atypical symptom profile that is characterized by preserved reactivity in mood, increased appetite, hypersomnia, a heavy sensation in the limbs, and interpersonal rejection sensitivity. In recent years, evidence has emerged that immunometabolic biological dysregulation is an important underlying pathophysiological mechanism in depression, which maps more consistently to atypical features. In the last few years human microbial residents have emerged as a key influencing variable associated with immunometabolic dysregulations in depression. The microbiome plays a critical role in the training and development of key components of the host's innate and adaptive immune systems, while the immune system orchestrates the maintenance of key features of the host-microbe symbiosis. Moreover, by being a metabolically active ecosystem commensal microbes may have a huge impact on signaling pathways, involved in underlying mechanisms leading to atypical depressive symptoms. In this review, we discuss the interplay between the microbiome and immunometabolic imbalance in the context of atypical depressive symptoms. Although research in this field is in its infancy, targeting biological determinants in more homogeneous clinical presentations of MDD may offer new avenues for the development of novel therapeutic strategies for treatment-resistant depression. This article is part of the Special Issue on Microbiome & the Brain: Mechanisms & Maladies." @default.
• W4376630272 created "2023-05-17" @default.
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• W4376630272 date "2023-09-01" @default.
• W4376630272 modified "2023-10-15" @default.
• W4376630272 title "Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation" @default.
• W4376630272 cites W1515023627 @default.
• W4376630272 cites W1534626330 @default.
• W4376630272 cites W1768927256 @default.
• W4376630272 cites W1816148962 @default.
• W4376630272 cites W1834036968 @default.
• W4376630272 cites W1844405070 @default.
• W4376630272 cites W1850288252 @default.
• W4376630272 cites W1864360976 @default.
• W4376630272 cites W1964244234 @default.
• W4376630272 cites W1972691065 @default.
• W4376630272 cites W1973267772 @default.
• W4376630272 cites W1973842058 @default.
• W4376630272 cites W1995250682 @default.
• W4376630272 cites W1996303231 @default.
• W4376630272 cites W1998325027 @default.
• W4376630272 cites W2000054651 @default.
• W4376630272 cites W2001585610 @default.
• W4376630272 cites W2006578694 @default.
• W4376630272 cites W2010371973 @default.
• W4376630272 cites W2011375052 @default.
• W4376630272 cites W2015662215 @default.
• W4376630272 cites W2021945985 @default.
• W4376630272 cites W2025665129 @default.
• W4376630272 cites W2026773834 @default.
• W4376630272 cites W2033386838 @default.
• W4376630272 cites W2034888144 @default.
• W4376630272 cites W2036849525 @default.
• W4376630272 cites W2039628081 @default.
• W4376630272 cites W2044506930 @default.
• W4376630272 cites W2045601755 @default.
• W4376630272 cites W2045833477 @default.
• W4376630272 cites W2047798386 @default.
• W4376630272 cites W2049163404 @default.
• W4376630272 cites W2055623573 @default.
• W4376630272 cites W2056978288 @default.
• W4376630272 cites W2059837321 @default.
• W4376630272 cites W2067273260 @default.
• W4376630272 cites W2067689880 @default.
• W4376630272 cites W2068080380 @default.
• W4376630272 cites W2069368135 @default.
• W4376630272 cites W2072016770 @default.
• W4376630272 cites W2073685674 @default.
• W4376630272 cites W2073802984 @default.
• W4376630272 cites W2076195605 @default.
• W4376630272 cites W2076394940 @default.
• W4376630272 cites W2077555853 @default.
• W4376630272 cites W2078820641 @default.
• W4376630272 cites W2078941925 @default.
• W4376630272 cites W2084158133 @default.
• W4376630272 cites W2088135834 @default.
• W4376630272 cites W2088841223 @default.
• W4376630272 cites W2092299253 @default.
• W4376630272 cites W2095483369 @default.
• W4376630272 cites W2096458622 @default.
• W4376630272 cites W2097572674 @default.
• W4376630272 cites W2101823049 @default.
• W4376630272 cites W2111574450 @default.
• W4376630272 cites W2113822705 @default.
• W4376630272 cites W2114058973 @default.
• W4376630272 cites W2114481621 @default.
• W4376630272 cites W2116159412 @default.
• W4376630272 cites W2121304943 @default.
• W4376630272 cites W2125065061 @default.
• W4376630272 cites W2127064468 @default.
• W4376630272 cites W2137252782 @default.
• W4376630272 cites W2137919415 @default.
• W4376630272 cites W2148132316 @default.
• W4376630272 cites W2148239264 @default.
• W4376630272 cites W2149074973 @default.
• W4376630272 cites W2152958471 @default.
• W4376630272 cites W2154248348 @default.
• W4376630272 cites W2156139207 @default.
• W4376630272 cites W2156150528 @default.
• W4376630272 cites W2157299931 @default.
• W4376630272 cites W2158218002 @default.
• W4376630272 cites W2162088497 @default.
• W4376630272 cites W2162904770 @default.
• W4376630272 cites W2163663214 @default.

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