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• W4376630897 endingPage "8411" @default.
• W4376630897 startingPage "8411" @default.
• W4376630897 abstract "Cluster of differentiation 44 (CD44) promotes tumor progression through the recruitment of growth factors and the acquisition of stemness, invasiveness, and drug resistance. CD44 has multiple isoforms including CD44 standard (CD44s) and CD44 variants (CD44v), which have common and unique functions in tumor development. Therefore, elucidating the function of each CD44 isoform in a tumor is essential for the establishment of CD44-targeting tumor therapy. We have established various anti-CD44s and anti-CD44v monoclonal antibodies (mAbs) through the immunization of CD44v3-10-overexpressed cells. In this study, we established C44Mab-6 (IgG1, kappa), which recognized the CD44 variant 3-encoded region (CD44v3), as determined via an enzyme-linked immunosorbent assay. C44Mab-6 reacted with CD44v3-10-overexpressed Chinese hamster ovary (CHO)-K1 cells (CHO/CD44v3-10) or some cancer cell lines (COLO205 and HSC-3) via flow cytometry. The apparent KD of C44Mab-6 for CHO/CD44v3-10, COLO205, and HSC-3 was 1.5 × 10-9 M, 6.3 × 10-9 M, and 1.9 × 10-9 M, respectively. C44Mab-6 could detect the CD44v3-10 in Western blotting and stained the formalin-fixed paraffin-embedded tumor sections in immunohistochemistry. These results indicate that C44Mab-6 is useful for detecting CD44v3 in various experiments and is expected for the application of tumor diagnosis and therapy." @default.
• W4376630897 created "2023-05-17" @default.
• W4376630897 creator A5009756622 @default.
• W4376630897 creator A5013109730 @default.
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• W4376630897 creator A5086351356 @default.
• W4376630897 date "2023-05-07" @default.
• W4376630897 modified "2023-10-16" @default.
• W4376630897 title "A Novel Anti-CD44 Variant 3 Monoclonal Antibody C44Mab-6 Was Established for Multiple Applications" @default.
• W4376630897 cites W179415334 @default.
• W4376630897 cites W1849896198 @default.
• W4376630897 cites W1969785980 @default.
• W4376630897 cites W1970944737 @default.
• W4376630897 cites W1972636316 @default.
• W4376630897 cites W1974873948 @default.
• W4376630897 cites W1983567075 @default.
• W4376630897 cites W1992676863 @default.
• W4376630897 cites W2000329589 @default.
• W4376630897 cites W2004935845 @default.
• W4376630897 cites W2023427658 @default.
• W4376630897 cites W2033702973 @default.
• W4376630897 cites W2033722377 @default.
• W4376630897 cites W2037632318 @default.
• W4376630897 cites W2041399911 @default.
• W4376630897 cites W2050200987 @default.
• W4376630897 cites W2059226282 @default.
• W4376630897 cites W2095782040 @default.
• W4376630897 cites W2105088175 @default.
• W4376630897 cites W2108836663 @default.
• W4376630897 cites W2112197935 @default.
• W4376630897 cites W2115707319 @default.
• W4376630897 cites W2117557895 @default.
• W4376630897 cites W2120884185 @default.
• W4376630897 cites W2123857764 @default.
• W4376630897 cites W2133678043 @default.
• W4376630897 cites W2139619397 @default.
• W4376630897 cites W2143250882 @default.
• W4376630897 cites W2146993009 @default.
• W4376630897 cites W2148583422 @default.
• W4376630897 cites W2153315863 @default.
• W4376630897 cites W2168662093 @default.
• W4376630897 cites W2182727161 @default.
• W4376630897 cites W2268290622 @default.
• W4376630897 cites W2269265109 @default.
• W4376630897 cites W2273498393 @default.
• W4376630897 cites W2430814939 @default.
• W4376630897 cites W2519879464 @default.
• W4376630897 cites W2559537906 @default.
• W4376630897 cites W2591836828 @default.
• W4376630897 cites W2754623626 @default.
• W4376630897 cites W2797047155 @default.
• W4376630897 cites W2797980880 @default.
• W4376630897 cites W2911299303 @default.
• W4376630897 cites W2911537936 @default.
• W4376630897 cites W2912022758 @default.
• W4376630897 cites W2917816084 @default.
• W4376630897 cites W2932386125 @default.
• W4376630897 cites W2944348047 @default.
• W4376630897 cites W2952571275 @default.
• W4376630897 cites W2978210224 @default.
• W4376630897 cites W3010519317 @default.
• W4376630897 cites W3014983698 @default.
• W4376630897 cites W3016348965 @default.
• W4376630897 cites W3049223928 @default.
• W4376630897 cites W3081941451 @default.
• W4376630897 cites W3093736393 @default.
• W4376630897 cites W3124914776 @default.
• W4376630897 cites W3152993484 @default.
• W4376630897 cites W3183562319 @default.
• W4376630897 cites W3194539234 @default.
• W4376630897 cites W3194769910 @default.
• W4376630897 cites W3195333672 @default.
• W4376630897 cites W3196616315 @default.
• W4376630897 cites W3206929109 @default.
• W4376630897 cites W3212339689 @default.
• W4376630897 cites W4200191473 @default.
• W4376630897 cites W4200247705 @default.
• W4376630897 cites W4214640706 @default.
• W4376630897 cites W4224927313 @default.
• W4376630897 cites W4225123768 @default.
• W4376630897 cites W4280517236 @default.
• W4376630897 cites W4284665919 @default.
• W4376630897 cites W4286256294 @default.
• W4376630897 cites W4297109380 @default.
• W4376630897 cites W4304789449 @default.
• W4376630897 cites W4309855135 @default.
• W4376630897 cites W4317106337 @default.
• W4376630897 cites W4318826672 @default.
• W4376630897 cites W4321091659 @default.
• W4376630897 cites W4322487249 @default.
• W4376630897 cites W4322496120 @default.
• W4376630897 cites W4365143025 @default.
• W4376630897 doi "https://doi.org/10.3390/ijms24098411" @default.
• W4376630897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37176118" @default.

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