Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376630976> ?p ?o ?g. }
- W4376630976 endingPage "8252" @default.
- W4376630976 startingPage "8252" @default.
- W4376630976 abstract "The intramolecular Heck reaction is a well-established strategy for natural product total synthesis. When constructing large rings, this reaction is also referred to as Heck macrocyclization, which has proved a viable avenue to access diverse naturally occurring macrocycles. Less noticed but likewise valuable, it has created novel macrocycles of non-natural origin that neither serve as nor derive from natural products. This review presents a systematic account of the title reaction in forging this non-natural subset of large rings, thereby addressing a topic rarely covered in the literature. Walking through two complementary sections, namely (1) drug discovery research and (2) synthetic methodology development, it demonstrates that beyond the well-known domain of natural product synthesis, Heck macrocyclization also plays a remarkable role in forming synthetic macrocycles, in particular macrocyclic drugs." @default.
- W4376630976 created "2023-05-17" @default.
- W4376630976 creator A5009812252 @default.
- W4376630976 creator A5018513015 @default.
- W4376630976 creator A5021428210 @default.
- W4376630976 creator A5050852420 @default.
- W4376630976 creator A5071286620 @default.
- W4376630976 date "2023-05-04" @default.
- W4376630976 modified "2023-10-16" @default.
- W4376630976 title "Heck Macrocyclization in Forging Non-Natural Large Rings including Macrocyclic Drugs" @default.
- W4376630976 cites W107409248 @default.
- W4376630976 cites W1568169946 @default.
- W4376630976 cites W1913218312 @default.
- W4376630976 cites W1952426211 @default.
- W4376630976 cites W1966043736 @default.
- W4376630976 cites W1968711897 @default.
- W4376630976 cites W1969470048 @default.
- W4376630976 cites W1971592878 @default.
- W4376630976 cites W1973439483 @default.
- W4376630976 cites W1973843371 @default.
- W4376630976 cites W1978882374 @default.
- W4376630976 cites W1979776755 @default.
- W4376630976 cites W1981754097 @default.
- W4376630976 cites W1983280580 @default.
- W4376630976 cites W1990322971 @default.
- W4376630976 cites W1990774649 @default.
- W4376630976 cites W1998233841 @default.
- W4376630976 cites W2004102526 @default.
- W4376630976 cites W2007224999 @default.
- W4376630976 cites W2013760130 @default.
- W4376630976 cites W2018422533 @default.
- W4376630976 cites W2022955258 @default.
- W4376630976 cites W2023018411 @default.
- W4376630976 cites W2023035837 @default.
- W4376630976 cites W2025718938 @default.
- W4376630976 cites W2026475743 @default.
- W4376630976 cites W2027497330 @default.
- W4376630976 cites W2027830921 @default.
- W4376630976 cites W2029488165 @default.
- W4376630976 cites W2029782677 @default.
- W4376630976 cites W2030246319 @default.
- W4376630976 cites W2030389679 @default.
- W4376630976 cites W2031032743 @default.
- W4376630976 cites W2033940007 @default.
- W4376630976 cites W2034343097 @default.
- W4376630976 cites W2037529225 @default.
- W4376630976 cites W2039632352 @default.
- W4376630976 cites W2050076623 @default.
- W4376630976 cites W2056304268 @default.
- W4376630976 cites W2058347971 @default.
- W4376630976 cites W2058364254 @default.
- W4376630976 cites W2059308648 @default.
- W4376630976 cites W2064313548 @default.
- W4376630976 cites W2065088072 @default.
- W4376630976 cites W2068844677 @default.
- W4376630976 cites W2078577005 @default.
- W4376630976 cites W2079891547 @default.
- W4376630976 cites W2090451426 @default.
- W4376630976 cites W2093086196 @default.
- W4376630976 cites W2093199737 @default.
- W4376630976 cites W2097028187 @default.
- W4376630976 cites W2105835273 @default.
- W4376630976 cites W2108982217 @default.
- W4376630976 cites W2111254482 @default.
- W4376630976 cites W2120145184 @default.
- W4376630976 cites W2124239919 @default.
- W4376630976 cites W2127484905 @default.
- W4376630976 cites W2133576799 @default.
- W4376630976 cites W2137566032 @default.
- W4376630976 cites W2140026331 @default.
- W4376630976 cites W2144873133 @default.
- W4376630976 cites W2145735125 @default.
- W4376630976 cites W2153013834 @default.
- W4376630976 cites W2162701869 @default.
- W4376630976 cites W2173651141 @default.
- W4376630976 cites W2178071937 @default.
- W4376630976 cites W2313316608 @default.
- W4376630976 cites W2316104631 @default.
- W4376630976 cites W2318318453 @default.
- W4376630976 cites W2325871124 @default.
- W4376630976 cites W2346961068 @default.
- W4376630976 cites W2414067561 @default.
- W4376630976 cites W2480186981 @default.
- W4376630976 cites W2484843303 @default.
- W4376630976 cites W2548401715 @default.
- W4376630976 cites W2565081035 @default.
- W4376630976 cites W2620136073 @default.
- W4376630976 cites W2623507637 @default.
- W4376630976 cites W2638186216 @default.
- W4376630976 cites W2678075585 @default.
- W4376630976 cites W2766251815 @default.
- W4376630976 cites W2766811789 @default.
- W4376630976 cites W2784414491 @default.
- W4376630976 cites W2791497066 @default.
- W4376630976 cites W2792370681 @default.
- W4376630976 cites W2792437842 @default.
- W4376630976 cites W2797175572 @default.
- W4376630976 cites W2826172614 @default.