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- W4376636265 abstract "Abstract This manuscript explains the effect of biologically important additives on the micellar behavior of an ethylene oxide‐propylene oxide (PEO 101 ‐PPO 56 ‐PEO 101 ) based linear block copolymer, Poloxamer 407.The effect of common pharmaceutical excipients and three vital amino acids viz. alanine, glycine, and lysine (Ala, Gly, and Lys) is examined with the help of cloud point (CP), dynamic light scattering (DLS), and small angle neutron scattering (SANS) techniques. The drug solubilization ability for the copolymer was checked for two model drugs Quercetin (QCT) and Ibuprofen (IBU) with the help of high‐performance liquid chromatography (HPLC) in the presence/absence of additives such as Ala, Gly, and Lys. The observed results reveal that higher amino acid concentrations, favor the solubilization of drug which can potentially benefit the use of these biocompatible copolymers in pharmaceutical and biopharma industries." @default.
- W4376636265 created "2023-05-17" @default.
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- W4376636265 date "2023-05-16" @default.
- W4376636265 modified "2023-10-17" @default.
- W4376636265 title "Amino acids induced modulations in linear <scp>PEO‐PPO‐PEO</scp> triblock copolymer microstructures and its exploration in prototypical drug solubilization" @default.
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- W4376636265 doi "https://doi.org/10.1002/jsde.12683" @default.
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