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• W4376636281 startingPage "113651" @default.
• W4376636281 abstract "Oncoprotein-induced transcript 3 (OIT3) facilitates macrophage M2 polarization and hepatocellular carcinoma (HCC) progression, however, whether OIT3 regulates tumor immunity remains largely unknown. Here we found that OIT3 was upregulated in HCC-associated macrophages, which inhibited CD4+ and CD8+ T-cell infiltration in the tumor microenvironment (TME). Mechanistically, OIT3 increased the expression of PD-L1 on tumor-associated macrophages (TAMs) by activating NF-κB signaling, blockade of NF-κB reversed the immunosuppressive activity of TAMs and dampens HCC tumorigenesis. Our findings provide the molecular basis for OIT3 enhancing tumor immunosuppression and highlighted a potential therapeutic strategy for targeting the TAMs of HCC." @default.
• W4376636281 created "2023-05-17" @default.
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• W4376636281 date "2023-07-01" @default.
• W4376636281 modified "2023-09-30" @default.
• W4376636281 title "Increased OIT3 in macrophages promotes PD-L1 expression and hepatocellular carcinogenesis via NF-κB signaling" @default.
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• W4376636281 doi "https://doi.org/10.1016/j.yexcr.2023.113651" @default.
• W4376636281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37201744" @default.
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