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• W4376636614 abstract "Abstract Objectives To determine if 17α-hydroxyprogesterone caproate (17OHPC) or vaginal progesterone use for patients at risk for preterm birth has changed since the publication of the 17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG) trial, and to assess which organizations’ (Food and Drug Administration’s [FDA], American College of Obstetrics and Gynecology’s [ACOG] or Society of Maternal Fetal Medicine’s [SMFM]) statements most influenced change. Methods Through a vignette-based physician survey, we sought to measure (by Likert scale) how counseling tendencies regarding 17OHPC and vaginal progesterone have changed since the PROLONG trial publication. Participants were also asked which organizations’ statements most influenced change. Results With response rate of 97 % (141/145), a pre-to-post PROLONG trial comparison revealed significant changes in counseling for progesterone. Respondents were less likely to recommend 17OHPC (p<0.001) and more likely to recommend vaginal (p<0.001). The FDA statement most influenced the decision not to recommend 17OHPC for the prevention of preterm birth (r=−0.23, p=0.005). Conclusions Providers have made significant changes in their counseling regarding progesterone use for patients at risk for preterm birth after the publication of the PRLONG trial." @default.
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• W4376636614 date "2023-05-16" @default.
• W4376636614 modified "2023-10-05" @default.
• W4376636614 title "Changes in use of 17-OHPC after the PROLONG trial: a physician survey" @default.
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• W4376636614 doi "https://doi.org/10.1515/jpm-2023-0085" @default.
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