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- W4376641005 abstract "A fundamental question in biology is how a eukaryotic cell type can be stably maintained through many rounds of DNA replication and cell division. In this paper, we investigate this question in a fungal species, Candida albicans, where two different cells types (white and opaque) arise from the same genome. Once formed, each cell type is stable for thousands of generations. Here, we investigate the mechanisms underlying opaque cell memory. Using an auxin-mediated degradation system, we rapidly removed Wor1, the primary transcription activator of the opaque state and, using a variety of methods, determined how long cells can maintain the opaque state. Within approximately 1 h of Wor1 destruction, opaque cells irreversibly lose their memory and switch to the white cell state. This observation rules out several competing models for cell memory and demonstrates that the continuous presence of Wor1 is needed to maintain the opaque cell state-even across a single cell division cycle. We also provide evidence for a threshold concentration of Wor1 in opaque cells, below which opaque cells irreversibly switch to white cells. Finally, we provide a detailed description of the gene expression changes that occur during this switch in cell types." @default.
- W4376641005 created "2023-05-17" @default.
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- W4376641005 date "2023-05-15" @default.
- W4376641005 modified "2023-10-14" @default.
- W4376641005 title "Cell-type memory in a single-cell eukaryote requires the continuous presence of a specific transcription regulator" @default.
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- W4376641005 doi "https://doi.org/10.1073/pnas.2220568120" @default.
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