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• W4376641006 abstract "Intracerebral hemorrhage (ICH) is a severe brain-injured disease accompanied by cerebral edema, inflammation, and subsequent neurological deficits. Mesenchymal stem cells (MSCs) transplantation has been used as a neuroprotective therapy in nervous system diseases because of its anti-inflammatory effect. Nevertheless, the biological characteristics of transplanted MSCs, including the survival rate, viability, and effectiveness, are restricted because of the severe inflammatory response after ICH. Therefore, improving the survival and viability of MSCs will provide a hopeful therapeutic efficacy for ICH. Notably, the biomedical applications of coordination chemistry-mediated metal-quercetin complex have been verified positively and studied extensively, including growth-promoting and imaging probes. Previous studies have shown that the iron-quercetin complex (IronQ) possesses extraordinary dual capabilities with a stimulating agent for cell growth and an imaging probe by magnetic resonance imaging (MRI). Therefore, we hypothesized that IronQ could improve the survival and viability of MSCs, displaying the anti-inflammation function in the treatment of ICH while also labeling MSCs for their tracking by MRI. This study aimed to explore the effects of MSCs with IronQ in regulating inflammation and further clarify their potential mechanisms.C57BL/6 male mice were utilized in this research. A collagenase I-induced ICH mice model was established and randomly separated into the model group (Model), quercetin gavage group (Quercetin), MSCs transplantation group (MSCs), and MSCs transplantation combined with IronQ group (MSCs + IronQ) after 24 h. Then, the neurological deficits score, brain water content (BWC), and protein expression, such as TNF-α, IL-6, NeuN, MBP, as well as GFAP, were investigated. We further measured the protein expression of Mincle and its downstream targets. Furthermore, the lipopolysaccharide (LPS)-induced BV2 cells were utilized to investigate the neuroprotection of conditioned medium of MSCs co-cultured with IronQ in vitro.We found that the combined treatment of MSCs with IronQ improved the inflammation-induced neurological deficits and BWC in vivo by inhibiting the Mincle/syk signaling pathway. Conditioned medium derived from MSCs co-cultured with IronQ decreased inflammation, Mincle, and its downstream targets in the LPS-induced BV2 cell line.These data suggested that the combined treatment exerts a collaborative effect in alleviating ICH-induced inflammatory response through the downregulation of the Mincle/syk signaling pathway following ICH, further improving the neurologic deficits and brain edema." @default.
• W4376641006 created "2023-05-17" @default.
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• W4376641006 date "2023-05-15" @default.
• W4376641006 modified "2023-09-27" @default.
• W4376641006 title "Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/syk signaling pathway" @default.
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• W4376641006 cites W1976010325 @default.
• W4376641006 cites W1981406821 @default.
• W4376641006 cites W1988464637 @default.
• W4376641006 cites W2001244796 @default.
• W4376641006 cites W2016575029 @default.
• W4376641006 cites W2020618233 @default.
• W4376641006 cites W2021859242 @default.
• W4376641006 cites W2031558559 @default.
• W4376641006 cites W2034555062 @default.
• W4376641006 cites W2035471044 @default.
• W4376641006 cites W2039008625 @default.
• W4376641006 cites W2044372075 @default.
• W4376641006 cites W2047218153 @default.
• W4376641006 cites W2054732923 @default.
• W4376641006 cites W2065429310 @default.
• W4376641006 cites W2066076668 @default.
• W4376641006 cites W2080684059 @default.
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• W4376641006 cites W2083600673 @default.
• W4376641006 cites W2102470119 @default.
• W4376641006 cites W2112161237 @default.
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• W4376641006 cites W2163320933 @default.
• W4376641006 cites W2208088507 @default.
• W4376641006 cites W2270333784 @default.
• W4376641006 cites W2283352688 @default.
• W4376641006 cites W2465441676 @default.
• W4376641006 cites W2495050981 @default.
• W4376641006 cites W2503531133 @default.
• W4376641006 cites W2557014978 @default.
• W4376641006 cites W2589481259 @default.
• W4376641006 cites W2592109973 @default.
• W4376641006 cites W2613058915 @default.
• W4376641006 cites W2613217394 @default.
• W4376641006 cites W2615735913 @default.
• W4376641006 cites W2743809422 @default.
• W4376641006 cites W2754685511 @default.
• W4376641006 cites W2894396118 @default.
• W4376641006 cites W2895676484 @default.
• W4376641006 cites W2906601044 @default.
• W4376641006 cites W2914368780 @default.
• W4376641006 cites W2930207669 @default.
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• W4376641006 cites W2969287275 @default.
• W4376641006 cites W2972974504 @default.
• W4376641006 cites W2996797923 @default.
• W4376641006 cites W3004561611 @default.
• W4376641006 cites W3014792005 @default.
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• W4376641006 cites W3023142433 @default.
• W4376641006 cites W3082470482 @default.
• W4376641006 cites W3082919977 @default.
• W4376641006 cites W3093258840 @default.
• W4376641006 cites W3098640872 @default.
• W4376641006 cites W3115742156 @default.
• W4376641006 cites W3126450731 @default.
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• W4376641006 doi "https://doi.org/10.1186/s13287-023-03369-6" @default.
• W4376641006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37189208" @default.
• W4376641006 hasPublicationYear "2023" @default.
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