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- W4376641134 startingPage "7339" @default.
- W4376641134 abstract "The conversion of easily available trifluoromethylarenes through C–F bond activation provides an attractive pathway for rapid access to difluorobenzylic substructures in producing pharmaceuticals and agrochemicals. However, recent advances in this area have been confined to C–C(H) bond construction, thus limiting the diversity of the accessible motifs. In contrast, the selective formation of a carbon–heteroatom bond via C–F bond functionalization, which enable fast and convenient access to diverse fluorine-containing motifs with high chemical diversity, remains a formidable synthetic challenge. Herein, we disclosed a Lewis acid promoted photoredox-catalyzed strategy for the construction of C–X (X = S, O or Se) bonds by single C(sp3)–F bond activation of trifluoromethylarenes, which enable the direct synthesis of medicinally interesting aryldifluoromethyl ether [ArCF2X– (X = S, O, or Se)] scaffolds. This method relies on readily available reagents and can tolerate a range of thiol, phenol, and selenol nucleophiles. Its utility was exemplified in the late-stage modifications of several pharmaceutical ingredients. Preliminary studies suggest two parallel pathways: a photocatalytic single electron-transfer (SET), and an electron donor–acceptor (EDA) process." @default.
- W4376641134 created "2023-05-17" @default.
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- W4376641134 date "2023-05-16" @default.
- W4376641134 modified "2023-10-10" @default.
- W4376641134 title "Construction of C–X (X = S, O, Se) Bonds <i>via</i> Lewis Acid-Promoted Functionalization of Trifluoromethylarenes" @default.
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- W4376641134 doi "https://doi.org/10.1021/acscatal.3c00669" @default.
- W4376641134 hasPublicationYear "2023" @default.
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