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• W4376641605 abstract "The African turquoise killifish is a powerful vertebrate system to study complex phenotypes at scale, including aging and age-related disease. Here, we develop a rapid and precise CRISPR/Cas9-mediated knock-in approach in the killifish. We show its efficient application to precisely insert fluorescent reporters of different sizes at various genomic loci in order to drive cell-type- and tissue-specific expression. This knock-in method should allow the establishment of humanized disease models and the development of cell-type-specific molecular probes for studying complex vertebrate biology." @default.
• W4376641605 created "2023-05-17" @default.
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• W4376641605 creator A5088357328 @default.
• W4376641605 date "2023-05-16" @default.
• W4376641605 modified "2023-10-18" @default.
• W4376641605 title "Rapid and precise genome engineering in a naturally short-lived vertebrate" @default.
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• W4376641605 doi "https://doi.org/10.7554/elife.80639" @default.
• W4376641605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37191291" @default.
• W4376641605 hasPublicationYear "2023" @default.
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