FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376642613> ?p ?o ?g. }

• W4376642613 endingPage "15" @default.
• W4376642613 startingPage "1" @default.
• W4376642613 abstract "The Zika virus (ZKV) is a single-stranded positive-sense, enveloped RNA virus. Zika infection during pregnancy can cause congenital microcephaly, Guillain-Barré syndrome, miscarriage, and other CNS abnormalities. The world needs safe and effective vaccinations to fight against ZIKV infection since vaccination is generally regarded as one of the most effective ways to prevent infectious diseases. In the present work, we used immunoinformatics and docking studies to construct a vaccine containing multi-epitopes using the structural and non-structural proteins of ZKV. The structural models of ZKV proteins (PrE, PrM, NS1, and NS2A) were constructed using Pyre2 and RaptorX servers. The epitopes of B-cell, T-cell (HTL and CTL), and IFN-γ were predicted, and each epitope's immunogenic nature and physiochemical properties were confirmed. As an adjuvant, the CPG-Oligodeoxynucleotide, an agonist of Toll-like receptor 9 (TLR9), is associated to cytotoxic T-lymphocytes (CTL) epitopes via PAPAP linker. To assess the binding affinity and the tendency of the designed vaccine to induce an immune response through TLR9, molecular docking was done. In the next step, molecular dynamics (MD) simulation to 100 nanoseconds (ns) was used to evaluate the stability of the interaction of the designed vaccine with TLR9. The designed vaccine is predicted to be highly antigenic, non-toxic, soluble, and stable with low flexibility in MD simulation. MD studies indicated that the finalized vaccine-TLR9 docked complex was stable during simulation time. The vaccine construct is able to stimulate both humoral and cellular immune responses. We suppose that our constructed model of the vaccine may have the ability to induce the host immune response against ZKV. Further studies, including in vitro and in vivo experimental analyses, are needed to prove the constructed vaccine's efficacy with multi-epitopes.Communicated by Ramaswamy H. Sarma." @default.
• W4376642613 created "2023-05-17" @default.
• W4376642613 creator A5027136722 @default.
• W4376642613 creator A5037066245 @default.
• W4376642613 creator A5039183758 @default.
• W4376642613 creator A5051682693 @default.
• W4376642613 creator A5080421221 @default.
• W4376642613 creator A5088997477 @default.
• W4376642613 date "2023-05-16" @default.
• W4376642613 modified "2023-09-28" @default.
• W4376642613 title "Rational design of B-cell and T-cell multi epitope-based vaccine against Zika virus, an <i>in silico</i> study" @default.
• W4376642613 cites W1710348905 @default.
• W4376642613 cites W1869576842 @default.
• W4376642613 cites W1973619678 @default.
• W4376642613 cites W1975120587 @default.
• W4376642613 cites W1975459052 @default.
• W4376642613 cites W1986191025 @default.
• W4376642613 cites W1992192767 @default.
• W4376642613 cites W1996423252 @default.
• W4376642613 cites W2012625502 @default.
• W4376642613 cites W2015176909 @default.
• W4376642613 cites W2035240910 @default.
• W4376642613 cites W2041711253 @default.
• W4376642613 cites W2055043387 @default.
• W4376642613 cites W2063996876 @default.
• W4376642613 cites W2065276673 @default.
• W4376642613 cites W2097874743 @default.
• W4376642613 cites W2102367710 @default.
• W4376642613 cites W2102592002 @default.
• W4376642613 cites W2110298304 @default.
• W4376642613 cites W2119292034 @default.
• W4376642613 cites W2123592990 @default.
• W4376642613 cites W2133458779 @default.
• W4376642613 cites W2137450588 @default.
• W4376642613 cites W2142678478 @default.
• W4376642613 cites W2152546486 @default.
• W4376642613 cites W2344557669 @default.
• W4376642613 cites W2411287810 @default.
• W4376642613 cites W2493891030 @default.
• W4376642613 cites W2507146114 @default.
• W4376642613 cites W2507444294 @default.
• W4376642613 cites W2561826764 @default.
• W4376642613 cites W2610067404 @default.
• W4376642613 cites W2626082249 @default.
• W4376642613 cites W2755831618 @default.
• W4376642613 cites W2771008397 @default.
• W4376642613 cites W2773161822 @default.
• W4376642613 cites W2783102765 @default.
• W4376642613 cites W2784648999 @default.
• W4376642613 cites W2789540974 @default.
• W4376642613 cites W2799293173 @default.
• W4376642613 cites W2804822363 @default.
• W4376642613 cites W2808607495 @default.
• W4376642613 cites W2898445359 @default.
• W4376642613 cites W2939743980 @default.
• W4376642613 cites W2943921080 @default.
• W4376642613 cites W2947044344 @default.
• W4376642613 cites W2966483993 @default.
• W4376642613 cites W2970860736 @default.
• W4376642613 cites W2990232930 @default.
• W4376642613 cites W3000149137 @default.
• W4376642613 cites W3012247520 @default.
• W4376642613 cites W3014716479 @default.
• W4376642613 cites W3032674291 @default.
• W4376642613 cites W3041135904 @default.
• W4376642613 cites W3041180919 @default.
• W4376642613 cites W3095325151 @default.
• W4376642613 cites W3101843443 @default.
• W4376642613 cites W3112376646 @default.
• W4376642613 cites W3119632070 @default.
• W4376642613 cites W3123558836 @default.
• W4376642613 cites W3130235632 @default.
• W4376642613 cites W3133269630 @default.
• W4376642613 cites W3134042813 @default.
• W4376642613 cites W3157940330 @default.
• W4376642613 cites W3184228771 @default.
• W4376642613 cites W3184890596 @default.
• W4376642613 cites W3196491939 @default.
• W4376642613 cites W3198505767 @default.
• W4376642613 cites W3198924522 @default.
• W4376642613 cites W3206720061 @default.
• W4376642613 cites W4200038834 @default.
• W4376642613 cites W4200509919 @default.
• W4376642613 cites W4205309725 @default.
• W4376642613 cites W4210293359 @default.
• W4376642613 cites W4210967474 @default.
• W4376642613 cites W4280592135 @default.
• W4376642613 cites W4307623921 @default.
• W4376642613 cites W4309737402 @default.
• W4376642613 cites W4310114240 @default.
• W4376642613 doi "https://doi.org/10.1080/07391102.2023.2213339" @default.
• W4376642613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37190978" @default.
• W4376642613 hasPublicationYear "2023" @default.
• W4376642613 type Work @default.
• W4376642613 citedByCount "0" @default.
• W4376642613 crossrefType "journal-article" @default.
• W4376642613 hasAuthorship W4376642613A5027136722 @default.
• W4376642613 hasAuthorship W4376642613A5037066245 @default.

• next