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• W4376642757 abstract "Abstract CRISPR-Cas9 is a popular gene-editing tool that allows researchers to introduce double-strand breaks to edit parts of the genome. CRISPR-Cas9 system is used more than other gene-editing tools because it is simple and easy to customize. However, Cas9 may produce unintended double-strand breaks in DNA, leading to off-target effects. There have been many improvements in the CRISPR-Cas system to control the off-target effect and improve the efficiency. The presence of a nuclease-deficient CRISPR-Cas system in several bacterial Tn7-like transposons inspires researchers to repurpose to direct the insertion of Tn7-like transposons instead of cleaving the target DNA, which will eventually limit the risk of off-target effects. Two transposon-encoded CRISPR-Cas systems have been experimentally confirmed. The first system, found in Tn7 like-transposon (Tn6677), is associated with the variant type I-F CRISPR-Cas system. The second one, found in Tn7 like-transposon (Tn5053), is related to the variant type V-K CRISPR-Cas system. This review describes the molecular and structural mechanisms of DNA targeting by the transposon-encoded type I-F CRISPR-Cas system, from assembly around the CRISPR-RNA (crRNA) to the initiation of transposition." @default.
• W4376642757 created "2023-05-17" @default.
• W4376642757 creator A5064159085 @default.
• W4376642757 creator A5091955041 @default.
• W4376642757 creator A5091955042 @default.
• W4376642757 date "2023-05-16" @default.
• W4376642757 modified "2023-09-30" @default.
• W4376642757 title "Insight into the molecular mechanism of the transposon-encoded type I-F CRISPR-Cas system" @default.
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• W4376642757 doi "https://doi.org/10.1186/s43141-023-00507-8" @default.
• W4376642757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37191877" @default.
• W4376642757 hasPublicationYear "2023" @default.
• W4376642757 type Work @default.
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• W4376642757 hasAuthorship W4376642757A5064159085 @default.
• W4376642757 hasAuthorship W4376642757A5091955041 @default.

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