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• W4376642768 abstract "Abstract Background Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD). However, it is unknown whether the ratio of forced vital capacity (FVC) to diffusing lung capacity for carbon monoxide (D LCO ) can identify PH in the patients with COPD and predict its prognosis. Methods The study population I included 937 COPD patients who were admitted to inpatient treatments from 2010 to 2017, and finally 750 patients were available to follow-up the 5-year all-cause mortality (study population II). Clinical characteristics of the study population were recorded. Results COPD patients with PH had a higher FVC/D LCO value compared with the patients without PH. The threshold for FVC/D LCO to identify PH in COPD patients was 0.44 l/mmol/min/kPa. Multivariate logistic regression analysis showed that FVC/D LCO was a significant predictor for PH in the patients with COPD. The study population II showed that the 5-year all-cause mortality of COPD patients was significantly higher in combined with PH group than without PH group. Compared with the survivor group, FVC/D LCO value was significantly increased in non-survivor group. The threshold for FVC/D LCO to predict 5-year all-cause mortality was 0.41 l/mmol/min/kPa. Kaplan–Meier survival curves showed that 5-year cumulative survival rate for COPD patients were significantly decreased when the value of FVC/D LCO was ≥ 0.41 l/mmol/min/kPa. Multivariate cox regression analysis showed that FVC/D LCO was an independent prognostic factor for 5-year all-cause mortality in COPD patients. Conclusion FVC/D LCO could identify PH in the patients with COPD and was an independent predictor for 5-year all-cause mortality of COPD." @default.
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• W4376642768 date "2023-05-15" @default.
• W4376642768 modified "2023-10-16" @default.
• W4376642768 title "FVC/DLCO identifies pulmonary hypertension and predicts 5-year all-cause mortality in patients with COPD" @default.
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• W4376642768 doi "https://doi.org/10.1186/s40001-023-01130-6" @default.
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