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- W4376642769 abstract "During inflammation, monocytes differentiate within tissues into macrophages (mo-Mac) or dendritic cells (mo-DC). Whether these two populations derive from alternative differentiation pathways or represent different stages along a continuum remains unclear. Here, we address this question using temporal single-cell RNA sequencing in an in vitro model, allowing the simultaneous differentiation of human mo-Mac and mo-DC. We find divergent differentiation paths, with a fate decision occurring within the first 24 h and confirm this result in vivo using a mouse model of sterile peritonitis. Using a computational approach, we identify candidate transcription factors potentially involved in monocyte fate commitment. We demonstrate that IRF1 is necessary for mo-Mac differentiation, independently of its role in regulating transcription of interferon-stimulated genes. In addition, we describe the transcription factors ZNF366 and MAFF as regulators of mo-DC development. Our results indicate that mo-Macs and mo-DCs represent two alternative cell fates requiring distinct transcription factors for their differentiation." @default.
- W4376642769 created "2023-05-17" @default.
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- W4376642769 date "2023-05-16" @default.
- W4376642769 modified "2023-10-18" @default.
- W4376642769 title "Monocytes differentiate along two alternative pathways during sterile inflammation" @default.
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- W4376642769 doi "https://doi.org/10.15252/embr.202256308" @default.
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- W4376642769 hasPublicationYear "2023" @default.
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