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- W4376642885 endingPage "e1010652" @default.
- W4376642885 startingPage "e1010652" @default.
- W4376642885 abstract "Liquid condensate droplets with distinct compositions of proteins and nucleic acids are widespread in biological cells. While it is known that such droplets, or compartments, can regulate irreversible protein aggregation, their effect on reversible self-assembly remains largely unexplored. In this article, we use kinetic theory and solution thermodynamics to investigate the effect of liquid-liquid phase separation on the reversible self-assembly of structures with well-defined sizes and architectures. We find that, when assembling subunits preferentially partition into liquid compartments, robustness against kinetic traps and maximum achievable assembly rates can be significantly increased. In particular, both the range of solution conditions leading to productive assembly and the corresponding assembly rates can increase by orders of magnitude. We analyze the rate equation predictions using simple scaling estimates to identify effects of liquid-liquid phase separation as a function of relevant control parameters. These results may elucidate self-assembly processes that underlie normal cellular functions or pathogenesis, and suggest strategies for designing efficient bottom-up assembly for nanomaterials applications." @default.
- W4376642885 created "2023-05-17" @default.
- W4376642885 creator A5072050512 @default.
- W4376642885 creator A5083616699 @default.
- W4376642885 date "2023-05-15" @default.
- W4376642885 modified "2023-09-30" @default.
- W4376642885 title "Self-assembly coupled to liquid-liquid phase separation" @default.
- W4376642885 cites W1503601820 @default.
- W4376642885 cites W1531818302 @default.
- W4376642885 cites W1912455695 @default.
- W4376642885 cites W1952608303 @default.
- W4376642885 cites W1967765906 @default.
- W4376642885 cites W1976576149 @default.
- W4376642885 cites W1979741071 @default.
- W4376642885 cites W1985178009 @default.
- W4376642885 cites W1985681646 @default.
- W4376642885 cites W1986850267 @default.
- W4376642885 cites W1992815312 @default.
- W4376642885 cites W1998381903 @default.
- W4376642885 cites W2000481871 @default.
- W4376642885 cites W2000805858 @default.
- W4376642885 cites W2003911773 @default.
- W4376642885 cites W2006696157 @default.
- W4376642885 cites W2009707635 @default.
- W4376642885 cites W2030886354 @default.
- W4376642885 cites W2031832448 @default.
- W4376642885 cites W2037663758 @default.
- W4376642885 cites W2049390938 @default.
- W4376642885 cites W2054352933 @default.
- W4376642885 cites W2054752603 @default.
- W4376642885 cites W2059615352 @default.
- W4376642885 cites W2060953134 @default.
- W4376642885 cites W2064524294 @default.
- W4376642885 cites W2064646996 @default.
- W4376642885 cites W2077553732 @default.
- W4376642885 cites W2083579241 @default.
- W4376642885 cites W2092786670 @default.
- W4376642885 cites W2102481876 @default.
- W4376642885 cites W2108083849 @default.
- W4376642885 cites W2108892218 @default.
- W4376642885 cites W2121563903 @default.
- W4376642885 cites W2121607469 @default.
- W4376642885 cites W2125371586 @default.
- W4376642885 cites W2137228172 @default.
- W4376642885 cites W2138884844 @default.
- W4376642885 cites W2139411356 @default.
- W4376642885 cites W2145260843 @default.
- W4376642885 cites W2146344101 @default.
- W4376642885 cites W2147537878 @default.
- W4376642885 cites W2150860983 @default.
- W4376642885 cites W2151325719 @default.
- W4376642885 cites W2155727418 @default.
- W4376642885 cites W2157319245 @default.
- W4376642885 cites W2157963288 @default.
- W4376642885 cites W2162452471 @default.
- W4376642885 cites W2164379005 @default.
- W4376642885 cites W2165259257 @default.
- W4376642885 cites W2306440131 @default.
- W4376642885 cites W2332758558 @default.
- W4376642885 cites W2371487873 @default.
- W4376642885 cites W2402791934 @default.
- W4376642885 cites W2403526287 @default.
- W4376642885 cites W2416638092 @default.
- W4376642885 cites W2509948508 @default.
- W4376642885 cites W2513980501 @default.
- W4376642885 cites W2590568317 @default.
- W4376642885 cites W2593868122 @default.
- W4376642885 cites W2594008643 @default.
- W4376642885 cites W2603000633 @default.
- W4376642885 cites W2604947514 @default.
- W4376642885 cites W2606756014 @default.
- W4376642885 cites W2611048578 @default.
- W4376642885 cites W2620662403 @default.
- W4376642885 cites W2731724500 @default.
- W4376642885 cites W2748927955 @default.
- W4376642885 cites W2751710506 @default.
- W4376642885 cites W2757076448 @default.
- W4376642885 cites W2765185939 @default.
- W4376642885 cites W2784384705 @default.
- W4376642885 cites W2793567263 @default.
- W4376642885 cites W2801157637 @default.
- W4376642885 cites W2802429563 @default.
- W4376642885 cites W2804416074 @default.
- W4376642885 cites W2807814444 @default.
- W4376642885 cites W2808847099 @default.
- W4376642885 cites W2809057270 @default.
- W4376642885 cites W2809265915 @default.
- W4376642885 cites W2883565396 @default.
- W4376642885 cites W2885013806 @default.
- W4376642885 cites W2886239953 @default.
- W4376642885 cites W2887204643 @default.
- W4376642885 cites W2888622657 @default.
- W4376642885 cites W2889732702 @default.
- W4376642885 cites W2891753890 @default.
- W4376642885 cites W2898777420 @default.
- W4376642885 cites W2902106157 @default.
- W4376642885 cites W2905613411 @default.
- W4376642885 cites W2912644423 @default.