FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376642983> ?p ?o ?g. }

• W4376642983 endingPage "139" @default.
• W4376642983 startingPage "126" @default.
• W4376642983 abstract "Two cycles of induction chemotherapy (IC) followed by 2 cycles of platinum-based concurrent chemoradiotherapy (CCRT) (2IC+2CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) is widely adopted but not evidence-confirmed. This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy, toxicity and cost-effectiveness.This real-world study from two epidemic centers used propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) analyses. The enrolled patients were divided into three groups based on treatment modality: Group A (2IC+2CCRT), Group B (3IC+2CCRT or 2IC+3CCRT) and Group C (3IC+3CCRT). Long-term survival, acute toxicities and cost-effectiveness were compared among the groups. We developed a prognostic model dividing the population into high- and low-risk cohorts, and survivals including overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS) and locoregional relapse-free survival (LRRFS) were compared among the three groups according to certain risk stratifications.Of 4,042 patients, 1,175 were enrolled, with 660, 419, and 96 included in Groups A, B and C, respectively. Five-year survivals were similar among the three groups after PSM and confirmed by IPTW. Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A (52.1% vs. 41.5% vs. 25.2%; 41.7% vs. 32.7% vs. 25.0%) as were grade 3-4 nausea/vomiting and oral mucositis (29.2% vs. 15.0% vs. 6.1%; 32.3% vs. 25.3% vs. 18.0%). Cost-effective analysis suggested that 2IC+2CCRT was the least expensive, while the health benefits were similar to those of the other groups. Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients, while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals, mainly reflected by LRRFS.In LA-NPC patients, 2IC+2CCRT was the optimal choice regarding efficacy, toxicity and cost-effectiveness; however, 2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high- and low-risk populations, respectively." @default.
• W4376642983 created "2023-05-17" @default.
• W4376642983 creator A5002940215 @default.
• W4376642983 creator A5008171524 @default.
• W4376642983 creator A5014823568 @default.
• W4376642983 creator A5015241142 @default.
• W4376642983 creator A5025216680 @default.
• W4376642983 creator A5039742042 @default.
• W4376642983 creator A5045080979 @default.
• W4376642983 creator A5047215778 @default.
• W4376642983 creator A5048052584 @default.
• W4376642983 creator A5049407298 @default.
• W4376642983 creator A5067778191 @default.
• W4376642983 creator A5070688328 @default.
• W4376642983 creator A5070961992 @default.
• W4376642983 creator A5081244781 @default.
• W4376642983 date "2023-01-01" @default.
• W4376642983 modified "2023-09-29" @default.
• W4376642983 title "Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making" @default.
• W4376642983 cites W2075324122 @default.
• W4376642983 cites W2102310008 @default.
• W4376642983 cites W2103371988 @default.
• W4376642983 cites W2110818436 @default.
• W4376642983 cites W2133134887 @default.
• W4376642983 cites W2223336507 @default.
• W4376642983 cites W2476849670 @default.
• W4376642983 cites W2526747727 @default.
• W4376642983 cites W2559861554 @default.
• W4376642983 cites W2566112167 @default.
• W4376642983 cites W2588073896 @default.
• W4376642983 cites W2779452291 @default.
• W4376642983 cites W2787937965 @default.
• W4376642983 cites W2789775641 @default.
• W4376642983 cites W2922035183 @default.
• W4376642983 cites W2947165726 @default.
• W4376642983 cites W2968914618 @default.
• W4376642983 cites W2977314049 @default.
• W4376642983 cites W2982375114 @default.
• W4376642983 cites W3012929857 @default.
• W4376642983 cites W3092264045 @default.
• W4376642983 cites W3113781210 @default.
• W4376642983 cites W3115988948 @default.
• W4376642983 cites W3118385481 @default.
• W4376642983 cites W3118937854 @default.
• W4376642983 cites W3128646645 @default.
• W4376642983 cites W3156377991 @default.
• W4376642983 cites W3156968563 @default.
• W4376642983 cites W3176595761 @default.
• W4376642983 cites W3205211596 @default.
• W4376642983 cites W3212312852 @default.
• W4376642983 cites W4200022474 @default.
• W4376642983 cites W4205629148 @default.
• W4376642983 cites W4285060175 @default.
• W4376642983 cites W4309409454 @default.
• W4376642983 cites W4309883132 @default.
• W4376642983 doi "https://doi.org/10.21147/j.issn.1000-9604.2023.02.04" @default.
• W4376642983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37180835" @default.
• W4376642983 hasPublicationYear "2023" @default.
• W4376642983 type Work @default.
• W4376642983 citedByCount "0" @default.
• W4376642983 crossrefType "journal-article" @default.
• W4376642983 hasAuthorship W4376642983A5002940215 @default.
• W4376642983 hasAuthorship W4376642983A5008171524 @default.
• W4376642983 hasAuthorship W4376642983A5014823568 @default.
• W4376642983 hasAuthorship W4376642983A5015241142 @default.
• W4376642983 hasAuthorship W4376642983A5025216680 @default.
• W4376642983 hasAuthorship W4376642983A5039742042 @default.
• W4376642983 hasAuthorship W4376642983A5045080979 @default.
• W4376642983 hasAuthorship W4376642983A5047215778 @default.
• W4376642983 hasAuthorship W4376642983A5048052584 @default.
• W4376642983 hasAuthorship W4376642983A5049407298 @default.
• W4376642983 hasAuthorship W4376642983A5067778191 @default.
• W4376642983 hasAuthorship W4376642983A5070688328 @default.
• W4376642983 hasAuthorship W4376642983A5070961992 @default.
• W4376642983 hasAuthorship W4376642983A5081244781 @default.
• W4376642983 hasBestOaLocation W43766429831 @default.
• W4376642983 hasConcept C126322002 @default.
• W4376642983 hasConcept C143998085 @default.
• W4376642983 hasConcept C17923572 @default.
• W4376642983 hasConcept C2776611710 @default.
• W4376642983 hasConcept C2776694085 @default.
• W4376642983 hasConcept C2778496288 @default.
• W4376642983 hasConcept C2778997737 @default.
• W4376642983 hasConcept C2908647359 @default.
• W4376642983 hasConcept C2909463153 @default.
• W4376642983 hasConcept C509974204 @default.
• W4376642983 hasConcept C71924100 @default.
• W4376642983 hasConcept C90924648 @default.
• W4376642983 hasConcept C99454951 @default.
• W4376642983 hasConceptScore W4376642983C126322002 @default.
• W4376642983 hasConceptScore W4376642983C143998085 @default.
• W4376642983 hasConceptScore W4376642983C17923572 @default.
• W4376642983 hasConceptScore W4376642983C2776611710 @default.
• W4376642983 hasConceptScore W4376642983C2776694085 @default.
• W4376642983 hasConceptScore W4376642983C2778496288 @default.
• W4376642983 hasConceptScore W4376642983C2778997737 @default.
• W4376642983 hasConceptScore W4376642983C2908647359 @default.
• W4376642983 hasConceptScore W4376642983C2909463153 @default.

• next