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• W4376643173 abstract "Dual modulation of the MAPK pathway with BRAF (e.g., dabrafenib) and MEK (e.g., trametinib) inhibitors has the potential to re-establish radioiodine (RAI) sensitivity in BRAF-mutated RAI-refractory (RAI-R)-differentiated thyroid carcinoma (DTC) cells. Here we showed that (1) double BRAF/MEK inhibition may still reach a significant redifferentiation in patients with a long-history RAI-R DTC and multiple previous treatments; (2) the addition of high RAI activities may obtain a significant structural response in such patients; and (3) a divergence between increasing thyroglobulin and structural response may be a reliable biomarker or redifferentiation. Accordingly, the add-on prescription of high activities of 131I should be considered in RAI-R patients under multikinase inhibitors with stable or responding structural disease and divergent increase of Tg levels." @default.
• W4376643173 created "2023-05-17" @default.
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• W4376643173 date "2023-05-16" @default.
• W4376643173 modified "2023-10-12" @default.
• W4376643173 title "Add-on radioiodine during long-term BRAF/MEK inhibition in patients with RAI-refractory thyroid cancers: a reasonable option?" @default.
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• W4376643173 doi "https://doi.org/10.1007/s12020-023-03388-6" @default.
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• W4376643173 hasPublicationYear "2023" @default.
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