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- W4376643805 abstract "Abstract Charting the chemical reaction space around the combination of carbonyls, amines, and isocyanoacetates allows the description of new multicomponent processes leading to a variety of unsaturated imidazolone scaffolds. The resulting compounds display the chromophore of the green fluorescent protein and the core of the natural product coelenterazine. Despite the competitive nature of the pathways involved, general protocols provide selective access to the desired chemotypes. Moreover, we describe unprecedented reactivity at the C‐2 position of the imidazolone core to directly afford C, S, and N‐derivatives featuring natural products (e.g. leucettamines), potent kinase inhibitors, and fluorescent probes with suitable optical and biological profiles." @default.
- W4376643805 created "2023-05-17" @default.
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- W4376643805 date "2023-06-02" @default.
- W4376643805 modified "2023-10-17" @default.
- W4376643805 title "Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds" @default.
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- W4376643805 doi "https://doi.org/10.1002/ange.202303889" @default.
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