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- W4376644540 endingPage "1979" @default.
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- W4376644540 abstract "Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Understanding the cancer mechanisms provides novel diagnostic, prognostic, and therapeutic markers for the management of HCC disease. In addition to genomic and epigenomic regulation, post-translational modification exerts a profound influence on protein functions and plays a critical role in regulating various biological processes. Protein glycosylation is one of the most common and complex post-translational modifications of newly synthesized proteins and acts as an important regulatory mechanism that is implicated in fundamental molecular and cell biology processes. Recent studies in glycobiology suggest that aberrant protein glycosylation in hepatocytes contributes to the malignant transformation to HCC by modulating a wide range of pro-tumorigenic signaling pathways. The dysregulated protein glycosylation regulates cancer growth, metastasis, stemness, immune evasion, and therapy resistance, and is regarded as a hallmark of HCC. Changes in protein glycosylation could serve as potential diagnostic, prognostic, and therapeutic factors in HCC. In this review, we summarize the functional importance, molecular mechanism, and clinical application of protein glycosylation alterations in HCC." @default.
- W4376644540 created "2023-05-17" @default.
- W4376644540 creator A5029941351 @default.
- W4376644540 creator A5067832646 @default.
- W4376644540 date "2023-05-16" @default.
- W4376644540 modified "2023-10-14" @default.
- W4376644540 title "Protein glycosylation alterations in hepatocellular carcinoma: function and clinical implications" @default.
- W4376644540 cites W1182461782 @default.
- W4376644540 cites W1503837407 @default.
- W4376644540 cites W1539891810 @default.
- W4376644540 cites W1564105650 @default.
- W4376644540 cites W1940064707 @default.
- W4376644540 cites W194638166 @default.
- W4376644540 cites W1965581644 @default.
- W4376644540 cites W1977423206 @default.
- W4376644540 cites W1978370116 @default.
- W4376644540 cites W1982056508 @default.
- W4376644540 cites W1987990773 @default.
- W4376644540 cites W1992648356 @default.
- W4376644540 cites W1996962547 @default.
- W4376644540 cites W2002760162 @default.
- W4376644540 cites W2009494587 @default.
- W4376644540 cites W2019577213 @default.
- W4376644540 cites W2020387650 @default.
- W4376644540 cites W2022717671 @default.
- W4376644540 cites W2035390577 @default.
- W4376644540 cites W2038703083 @default.
- W4376644540 cites W2044342281 @default.
- W4376644540 cites W2050862868 @default.
- W4376644540 cites W2052644289 @default.
- W4376644540 cites W2056746886 @default.
- W4376644540 cites W2062264822 @default.
- W4376644540 cites W2068713367 @default.
- W4376644540 cites W2072615276 @default.
- W4376644540 cites W2078042241 @default.
- W4376644540 cites W2080198588 @default.
- W4376644540 cites W2084541252 @default.
- W4376644540 cites W2088872460 @default.
- W4376644540 cites W2089281893 @default.
- W4376644540 cites W2099391010 @default.
- W4376644540 cites W2110823050 @default.
- W4376644540 cites W2122372709 @default.
- W4376644540 cites W2124634982 @default.
- W4376644540 cites W2132240438 @default.
- W4376644540 cites W2133936296 @default.
- W4376644540 cites W2137548222 @default.
- W4376644540 cites W2156381487 @default.
- W4376644540 cites W2162230740 @default.
- W4376644540 cites W2168824556 @default.
- W4376644540 cites W2338407080 @default.
- W4376644540 cites W2343372431 @default.
- W4376644540 cites W2409983941 @default.
- W4376644540 cites W2430785102 @default.
- W4376644540 cites W2472409041 @default.
- W4376644540 cites W2483556952 @default.
- W4376644540 cites W2557684364 @default.
- W4376644540 cites W2564893946 @default.
- W4376644540 cites W2571232914 @default.
- W4376644540 cites W2588207394 @default.
- W4376644540 cites W2590436775 @default.
- W4376644540 cites W2597349164 @default.
- W4376644540 cites W2610870630 @default.
- W4376644540 cites W2615422130 @default.
- W4376644540 cites W2751553600 @default.
- W4376644540 cites W2755282673 @default.
- W4376644540 cites W2762561303 @default.
- W4376644540 cites W2768159696 @default.
- W4376644540 cites W2792056622 @default.
- W4376644540 cites W2794128825 @default.
- W4376644540 cites W2886344763 @default.
- W4376644540 cites W2889930164 @default.
- W4376644540 cites W2891602686 @default.
- W4376644540 cites W2913412475 @default.
- W4376644540 cites W2914607380 @default.
- W4376644540 cites W2921437380 @default.
- W4376644540 cites W2922345574 @default.
- W4376644540 cites W2940585168 @default.
- W4376644540 cites W2960011166 @default.
- W4376644540 cites W2961185444 @default.
- W4376644540 cites W3012402902 @default.
- W4376644540 cites W3019798094 @default.
- W4376644540 cites W3044945170 @default.
- W4376644540 cites W3048417136 @default.
- W4376644540 cites W3106476406 @default.
- W4376644540 cites W3109485037 @default.
- W4376644540 cites W3110927983 @default.
- W4376644540 cites W3128646645 @default.
- W4376644540 cites W3139217643 @default.
- W4376644540 cites W3156313785 @default.
- W4376644540 cites W3186932934 @default.
- W4376644540 cites W3200917765 @default.
- W4376644540 cites W4205603953 @default.
- W4376644540 cites W4214921055 @default.
- W4376644540 cites W4225124494 @default.
- W4376644540 cites W4245881395 @default.
- W4376644540 cites W4282977379 @default.
- W4376644540 cites W4286255685 @default.
- W4376644540 cites W4292314675 @default.