Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376644958> ?p ?o ?g. }
- W4376644958 abstract "Summary The human genome is packaged into the three-dimensional (3D) nucleus and organized into functional units known as topologically associating domains (TADs) and chromatin loops. Recent studies show that the 3D genome can be modified by genome structural variants (SVs) through disrupting higher-order chromatin organizations such as TADs, which play an essential role in insulating genes from aberrant regulation by regulatory elements outside TADs. Here, we have developed an integrative Hi-C analysis pipeline to generate a comprehensive catalog of TADs, TAD boundaries, and loops in human genomes to fill the gap of limited resources. We identified 2,293 TADs and 6,810 sub-TADs missing in the previously released TADs of GM12878. We then quantified the impact of SVs overlapping with TAD boundaries and observed that two SVs could significantly alter chromatin architecture leading to abnormal expression and splicing of genes associated with human diseases." @default.
- W4376644958 created "2023-05-17" @default.
- W4376644958 creator A5002025948 @default.
- W4376644958 creator A5008364714 @default.
- W4376644958 creator A5014870107 @default.
- W4376644958 creator A5026460408 @default.
- W4376644958 creator A5038698652 @default.
- W4376644958 creator A5055295290 @default.
- W4376644958 creator A5057167506 @default.
- W4376644958 creator A5060291693 @default.
- W4376644958 creator A5066769108 @default.
- W4376644958 creator A5067570776 @default.
- W4376644958 creator A5071136927 @default.
- W4376644958 date "2023-05-15" @default.
- W4376644958 modified "2023-10-18" @default.
- W4376644958 title "A comprehensive catalog of 3D genome organization in diverse human genomes facilitates understanding of the impact of structural variation on chromatin structure" @default.
- W4376644958 cites W1859117663 @default.
- W4376644958 cites W1969830384 @default.
- W4376644958 cites W1973062929 @default.
- W4376644958 cites W2007104998 @default.
- W4376644958 cites W2018658338 @default.
- W4376644958 cites W2067245109 @default.
- W4376644958 cites W2070021921 @default.
- W4376644958 cites W2078526277 @default.
- W4376644958 cites W2099328768 @default.
- W4376644958 cites W2102368172 @default.
- W4376644958 cites W2102619694 @default.
- W4376644958 cites W2103441770 @default.
- W4376644958 cites W2104549677 @default.
- W4376644958 cites W2144824933 @default.
- W4376644958 cites W2163412235 @default.
- W4376644958 cites W2169500338 @default.
- W4376644958 cites W2247766769 @default.
- W4376644958 cites W2340540054 @default.
- W4376644958 cites W2416744721 @default.
- W4376644958 cites W2481029670 @default.
- W4376644958 cites W2493763501 @default.
- W4376644958 cites W2534005127 @default.
- W4376644958 cites W2555451680 @default.
- W4376644958 cites W2584394140 @default.
- W4376644958 cites W2625231465 @default.
- W4376644958 cites W2755736028 @default.
- W4376644958 cites W2782160930 @default.
- W4376644958 cites W2800968671 @default.
- W4376644958 cites W2803256172 @default.
- W4376644958 cites W2803273274 @default.
- W4376644958 cites W2891348030 @default.
- W4376644958 cites W2891870314 @default.
- W4376644958 cites W2904120442 @default.
- W4376644958 cites W2906147404 @default.
- W4376644958 cites W2918573139 @default.
- W4376644958 cites W2936970738 @default.
- W4376644958 cites W2937151182 @default.
- W4376644958 cites W2948120322 @default.
- W4376644958 cites W2949062400 @default.
- W4376644958 cites W2950049721 @default.
- W4376644958 cites W2951050465 @default.
- W4376644958 cites W2951322997 @default.
- W4376644958 cites W2951521970 @default.
- W4376644958 cites W2953462601 @default.
- W4376644958 cites W2960979937 @default.
- W4376644958 cites W2991011261 @default.
- W4376644958 cites W2991505041 @default.
- W4376644958 cites W2999585791 @default.
- W4376644958 cites W3004590664 @default.
- W4376644958 cites W3004613412 @default.
- W4376644958 cites W3007609047 @default.
- W4376644958 cites W3008209398 @default.
- W4376644958 cites W3008783161 @default.
- W4376644958 cites W3017323102 @default.
- W4376644958 cites W3030907164 @default.
- W4376644958 cites W3036269769 @default.
- W4376644958 cites W3085770027 @default.
- W4376644958 cites W3106143834 @default.
- W4376644958 cites W3112752014 @default.
- W4376644958 cites W3116380299 @default.
- W4376644958 cites W3124312836 @default.
- W4376644958 cites W3126332871 @default.
- W4376644958 cites W3130788486 @default.
- W4376644958 cites W3156421803 @default.
- W4376644958 cites W3163694527 @default.
- W4376644958 cites W3178078266 @default.
- W4376644958 cites W3183256071 @default.
- W4376644958 cites W3189991236 @default.
- W4376644958 cites W4220999759 @default.
- W4376644958 cites W4223416923 @default.
- W4376644958 cites W4225279860 @default.
- W4376644958 cites W4296709993 @default.
- W4376644958 cites W4307659092 @default.
- W4376644958 cites W4308022950 @default.
- W4376644958 cites W4308038395 @default.
- W4376644958 cites W4317373375 @default.
- W4376644958 cites W4323657474 @default.
- W4376644958 cites W4366594168 @default.
- W4376644958 doi "https://doi.org/10.1101/2023.05.15.540856" @default.
- W4376644958 hasPublicationYear "2023" @default.
- W4376644958 type Work @default.
- W4376644958 citedByCount "0" @default.
- W4376644958 crossrefType "posted-content" @default.
- W4376644958 hasAuthorship W4376644958A5002025948 @default.