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• W4376647346 abstract "Aim: Human respiratory syncytial virus (HRSV) is a common cause of respiratory infections, particularly in infants and the elderly. Ribavirin is the only US FDA-approved antiviral drug for HRSV infection, but it has unwanted side effects. Methods: We engineered an shRNA targeting the HRSV- M gene to antagonize HRSV replication. Results: The results showed that shRNA had a similarly significant reduction in viral load (99.8%) as ribavirin. In addition, combined treatment with ribavirin and M-shRNA resulted in a significant reduction in viral load compared with ribavirin or M-shRNA alone. Conclusion: These results suggest that M-shRNA could be a potential new inhibitor of HRSV replication and could offer a safer and more effective treatment option for HRSV infection in the future." @default.
• W4376647346 created "2023-05-17" @default.
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• W4376647346 date "2023-04-01" @default.
• W4376647346 modified "2023-09-28" @default.
• W4376647346 title "Short hairpin RNA-mediated matrix gene silencing of human respiratory syncytial virus as a potent antiviral strategy" @default.
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• W4376647346 doi "https://doi.org/10.2217/fvl-2022-0207" @default.
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