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- W4376647603 abstract "Abstract N-Acetylcysteine (NAC) is a precursor of Glutathione (GSH) which possess an immense potential of mucolytic, anti-inflammatory and antioxidant properties against several diseases including tuberculosis. Since last several decades, NAC is being primarily used to treat lung conditions as well as paracetamol-induced liver toxicity However, NAC exhibited potential antimycobacterial activity through several mechanism including immunomodulation, enhancement of GSH level, and by direct antimycobacterial effect. Herein, we synthesized and characterized lactose coated N-acetylcysteine loaded PLGA composites (NAC-PLGA@Cs) by double emulsion solvent evaporation technique. The physicochemical characterization studies revealed the compatibility of the drug with excipients. Moreover, NAC-PLGA@Cs showed particle size with 310 ± 5.5nm, PDI with 0.15 ± 0.1, and zeta potential with − 11.5 ± 0.4 mV. In vitro release study suggested the biphasic release profile. Likewise, in vitro lung deposition studies revealed remarkable lung deposition parameters, indicating effective particles size for efficient pulmonary delivery. Additionally, in vitro study for antimycobacterial activity exhibited superior antibacterial activity against MTB H37Rv. Subsequently, we hypothesized that NAC incorporated PLGA composites could be a novel approach in the battle of fighting for pulmonary tuberculosis." @default.
- W4376647603 created "2023-05-17" @default.
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- W4376647603 date "2023-05-16" @default.
- W4376647603 modified "2023-10-17" @default.
- W4376647603 title "Inhalable N-Acetylcysteine loaded PLGA composites for Tuberculosis: In Vitro Aersolization and Efficacy Studies" @default.
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- W4376647603 doi "https://doi.org/10.21203/rs.3.rs-2918673/v1" @default.
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