Matches in SemOpenAlex for { <https://semopenalex.org/work/W43768156> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W43768156 endingPage "1255" @default.
- W43768156 startingPage "1252" @default.
- W43768156 abstract "Abstract Monocytes are thought to play a role in host resistance to tumor cell growth in animals and humans. In addition, platelets are known to be involved in tumor metastases. To investigate the interaction of these two cell types and their effect on tumor cells, human monocytes and platelets were examined using an in vitro monocyte-tumor cell cytotoxicity assay. Monocytes alone resulted in 32% +/- 1.5 (mean +/- SEM) tumor cell kill. When platelets were added to monocytes in a 1:1 ratio, an increase in cytotoxicity to 61% +/- 3.2 was observed. The cytotoxicity noted when platelets were added to a fixed number of monocytes and tumor cells was dependent on the number of platelets added. A decrease in cytotoxicity from 32% +/- 1.5 to 12% +/- 2.3 was observed when contaminating platelets were removed from monocyte preparations. Platelets added to tumor cells in the absence of any monocytes were also toxic, resulting in a maximum kill of 95% at a 4:1 platelet/tumor cell ratio. Secreted products of freshly isolated platelets may be responsible for much of the observed cytotoxicity, since supernatants from the platelets were toxic for tumor cells. Platelets pretreated with a cyclooxygenase inhibitor (ASA) or a lipoxygenase inhibitor had decreased cytotoxicity compared with untreated platelets. Our results indicate that products of platelet arachidonate metabolism are toxic for tumor cell lines. They also suggest that the role of the platelet must be considered when studying monocyte-tumor cell cytotoxicity." @default.
- W43768156 created "2016-06-24" @default.
- W43768156 creator A5002515721 @default.
- W43768156 creator A5027906895 @default.
- W43768156 creator A5069993222 @default.
- W43768156 creator A5081513059 @default.
- W43768156 date "1985-05-01" @default.
- W43768156 modified "2023-09-27" @default.
- W43768156 title "Human platelets exert cytotoxic effects on tumor cells" @default.
- W43768156 cites W1528801751 @default.
- W43768156 cites W1549587599 @default.
- W43768156 cites W1601200565 @default.
- W43768156 cites W1975747378 @default.
- W43768156 cites W1977070858 @default.
- W43768156 cites W1993725936 @default.
- W43768156 cites W2012285989 @default.
- W43768156 cites W2015211989 @default.
- W43768156 cites W2019314531 @default.
- W43768156 cites W2019689542 @default.
- W43768156 cites W2020340572 @default.
- W43768156 cites W2026266325 @default.
- W43768156 cites W2030114520 @default.
- W43768156 cites W2035208571 @default.
- W43768156 cites W2041489131 @default.
- W43768156 cites W2043660021 @default.
- W43768156 cites W2082547823 @default.
- W43768156 cites W2086864461 @default.
- W43768156 cites W2135212714 @default.
- W43768156 cites W2396508260 @default.
- W43768156 cites W2471774619 @default.
- W43768156 cites W2950137151 @default.
- W43768156 doi "https://doi.org/10.1182/blood.v65.5.1252.1252" @default.
- W43768156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3922450" @default.
- W43768156 hasPublicationYear "1985" @default.
- W43768156 type Work @default.
- W43768156 sameAs 43768156 @default.
- W43768156 citedByCount "50" @default.
- W43768156 countsByYear W437681562012 @default.
- W43768156 countsByYear W437681562013 @default.
- W43768156 countsByYear W437681562014 @default.
- W43768156 countsByYear W437681562015 @default.
- W43768156 countsByYear W437681562016 @default.
- W43768156 countsByYear W437681562017 @default.
- W43768156 countsByYear W437681562018 @default.
- W43768156 countsByYear W437681562020 @default.
- W43768156 countsByYear W437681562021 @default.
- W43768156 countsByYear W437681562022 @default.
- W43768156 crossrefType "journal-article" @default.
- W43768156 hasAuthorship W43768156A5002515721 @default.
- W43768156 hasAuthorship W43768156A5027906895 @default.
- W43768156 hasAuthorship W43768156A5069993222 @default.
- W43768156 hasAuthorship W43768156A5081513059 @default.
- W43768156 hasBestOaLocation W437681561 @default.
- W43768156 hasConcept C109316439 @default.
- W43768156 hasConcept C153911025 @default.
- W43768156 hasConcept C154317977 @default.
- W43768156 hasConcept C185592680 @default.
- W43768156 hasConcept C202751555 @default.
- W43768156 hasConcept C203014093 @default.
- W43768156 hasConcept C2781184567 @default.
- W43768156 hasConcept C502942594 @default.
- W43768156 hasConcept C54355233 @default.
- W43768156 hasConcept C55493867 @default.
- W43768156 hasConcept C81885089 @default.
- W43768156 hasConcept C86803240 @default.
- W43768156 hasConcept C89560881 @default.
- W43768156 hasConceptScore W43768156C109316439 @default.
- W43768156 hasConceptScore W43768156C153911025 @default.
- W43768156 hasConceptScore W43768156C154317977 @default.
- W43768156 hasConceptScore W43768156C185592680 @default.
- W43768156 hasConceptScore W43768156C202751555 @default.
- W43768156 hasConceptScore W43768156C203014093 @default.
- W43768156 hasConceptScore W43768156C2781184567 @default.
- W43768156 hasConceptScore W43768156C502942594 @default.
- W43768156 hasConceptScore W43768156C54355233 @default.
- W43768156 hasConceptScore W43768156C55493867 @default.
- W43768156 hasConceptScore W43768156C81885089 @default.
- W43768156 hasConceptScore W43768156C86803240 @default.
- W43768156 hasConceptScore W43768156C89560881 @default.
- W43768156 hasIssue "5" @default.
- W43768156 hasLocation W437681561 @default.
- W43768156 hasOpenAccess W43768156 @default.
- W43768156 hasPrimaryLocation W437681561 @default.
- W43768156 hasRelatedWork W1489200483 @default.
- W43768156 hasRelatedWork W1500704576 @default.
- W43768156 hasRelatedWork W1607956894 @default.
- W43768156 hasRelatedWork W170890397 @default.
- W43768156 hasRelatedWork W1990434843 @default.
- W43768156 hasRelatedWork W2058463700 @default.
- W43768156 hasRelatedWork W2460820151 @default.
- W43768156 hasRelatedWork W261645828 @default.
- W43768156 hasRelatedWork W4206956544 @default.
- W43768156 hasRelatedWork W4319867226 @default.
- W43768156 hasVolume "65" @default.
- W43768156 isParatext "false" @default.
- W43768156 isRetracted "false" @default.
- W43768156 magId "43768156" @default.
- W43768156 workType "article" @default.