Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376862912> ?p ?o ?g. }
- W4376862912 abstract "Abstract Activated alkyl halides have been extensively explored to generate alkyl radicals with Ru‐ and Ir‐ photocatalysts for 1,2‐difunctionalization of alkenes, but unactivated alkyl bromides remain challenging substrates due to their strong reduction potential. Here we report a three‐component 1,2‐difunctionalization reaction of alkenes, unactivated alkyl bromides and nucleophiles (e.g., amines and indoles) using a trinuclear gold catalyst [Au 3 (tppm) 2 ](OTf) 3 . It can achieve the 1,2‐aminoalkylation and 1,2‐alkylarylation readily. This protocol has a broad reaction scope and excellent functional group compatibility (>100 examples with up to 96 % yield). It also affords a robust formal [2+2+1] cyclization strategy for the concise construction of pyrrolidine skeletons under mild reaction conditions. Mechanistic studies support an inner‐sphere single electron transfer pathway for the successful cleavage of inert C−Br bonds." @default.
- W4376862912 created "2023-05-18" @default.
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- W4376862912 date "2023-06-14" @default.
- W4376862912 modified "2023-10-01" @default.
- W4376862912 title "Trinuclear Gold‐Catalyzed 1,2‐Difunctionalization of Alkenes" @default.
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- W4376862912 doi "https://doi.org/10.1002/ange.202305121" @default.
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