Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376867097> ?p ?o ?g. }
- W4376867097 abstract "Pulmonary hypertension (PH) is a disease of pulmonary artery stenosis and blockage caused by abnormal pulmonary artery smooth muscle cells (PASMCs), with high morbidity and mortality. High levels of reactive oxygen species (ROS) in pulmonary arteries play a crucial role in inducing phenotypic switch and abnormal proliferation of PASMCs. However, antioxidants are rarely approved for the treatment of PH because of a lack of targeting and low bioavailability. In this study, the presence of an enhanced permeability and retention effect (EPR)-like effect in the pulmonary arteries of PH is revealed by tissue transmission electron microscopy (TEM). Subsequently, for the first time, tungsten-based polyoxometalate nanodots (WNDs) are developed with potent elimination of multiple ROS for efficient treatment of PH thanks to the high proportion of reduced W5+ . WNDs are effectively enriched in the pulmonary artery by intravenous injection because of the EPR-like effect of PH, and significantly prevent the abnormal proliferation of PASMCs, greatly improve the remodeling of pulmonary arteries, and ultimately improve right heart function. In conclusion, this work provides a novel and effective solution to the dilemma of targeting ROS for the treatment of PH." @default.
- W4376867097 created "2023-05-18" @default.
- W4376867097 creator A5012207989 @default.
- W4376867097 creator A5015677261 @default.
- W4376867097 creator A5028567688 @default.
- W4376867097 creator A5029106854 @default.
- W4376867097 creator A5039839914 @default.
- W4376867097 creator A5046227483 @default.
- W4376867097 creator A5052304130 @default.
- W4376867097 creator A5053384167 @default.
- W4376867097 creator A5057287134 @default.
- W4376867097 date "2023-05-26" @default.
- W4376867097 modified "2023-10-17" @default.
- W4376867097 title "Natural Targeting Potent ROS‐Eliminating Tungsten‐Based Polyoxometalate Nanodots for Efficient Treatment of Pulmonary Hypertension" @default.
- W4376867097 cites W164209717 @default.
- W4376867097 cites W2065296615 @default.
- W4376867097 cites W2473222548 @default.
- W4376867097 cites W2503078084 @default.
- W4376867097 cites W2603129724 @default.
- W4376867097 cites W2742185174 @default.
- W4376867097 cites W2766499814 @default.
- W4376867097 cites W2775303211 @default.
- W4376867097 cites W2789769541 @default.
- W4376867097 cites W2889542087 @default.
- W4376867097 cites W2904654692 @default.
- W4376867097 cites W2920393150 @default.
- W4376867097 cites W2923947489 @default.
- W4376867097 cites W2937661365 @default.
- W4376867097 cites W2989461024 @default.
- W4376867097 cites W3001839380 @default.
- W4376867097 cites W3004876233 @default.
- W4376867097 cites W3005522739 @default.
- W4376867097 cites W3009887490 @default.
- W4376867097 cites W3010302032 @default.
- W4376867097 cites W3010479646 @default.
- W4376867097 cites W3040743432 @default.
- W4376867097 cites W3080667847 @default.
- W4376867097 cites W3082710598 @default.
- W4376867097 cites W3093069358 @default.
- W4376867097 cites W3097279097 @default.
- W4376867097 cites W3119793303 @default.
- W4376867097 cites W3134630372 @default.
- W4376867097 cites W3158263762 @default.
- W4376867097 cites W3161204644 @default.
- W4376867097 cites W3163284945 @default.
- W4376867097 cites W3170695525 @default.
- W4376867097 cites W3176618862 @default.
- W4376867097 cites W3200572097 @default.
- W4376867097 cites W3200693421 @default.
- W4376867097 cites W3201161912 @default.
- W4376867097 cites W4214702060 @default.
- W4376867097 cites W4223504984 @default.
- W4376867097 cites W4225152761 @default.
- W4376867097 cites W4233798073 @default.
- W4376867097 cites W4281260882 @default.
- W4376867097 cites W4282565626 @default.
- W4376867097 cites W4293217384 @default.
- W4376867097 cites W4293257851 @default.
- W4376867097 cites W4295182853 @default.
- W4376867097 cites W4296122391 @default.
- W4376867097 cites W4309825977 @default.
- W4376867097 cites W4319825915 @default.
- W4376867097 doi "https://doi.org/10.1002/adhm.202300252" @default.
- W4376867097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37196347" @default.
- W4376867097 hasPublicationYear "2023" @default.
- W4376867097 type Work @default.
- W4376867097 citedByCount "0" @default.
- W4376867097 crossrefType "journal-article" @default.
- W4376867097 hasAuthorship W4376867097A5012207989 @default.
- W4376867097 hasAuthorship W4376867097A5015677261 @default.
- W4376867097 hasAuthorship W4376867097A5028567688 @default.
- W4376867097 hasAuthorship W4376867097A5029106854 @default.
- W4376867097 hasAuthorship W4376867097A5039839914 @default.
- W4376867097 hasAuthorship W4376867097A5046227483 @default.
- W4376867097 hasAuthorship W4376867097A5052304130 @default.
- W4376867097 hasAuthorship W4376867097A5053384167 @default.
- W4376867097 hasAuthorship W4376867097A5057287134 @default.
- W4376867097 hasConcept C126322002 @default.
- W4376867097 hasConcept C164705383 @default.
- W4376867097 hasConcept C185592680 @default.
- W4376867097 hasConcept C192562407 @default.
- W4376867097 hasConcept C2777714996 @default.
- W4376867097 hasConcept C2780930700 @default.
- W4376867097 hasConcept C2780940725 @default.
- W4376867097 hasConcept C2781244666 @default.
- W4376867097 hasConcept C48349386 @default.
- W4376867097 hasConcept C55493867 @default.
- W4376867097 hasConcept C71924100 @default.
- W4376867097 hasConcept C98274493 @default.
- W4376867097 hasConceptScore W4376867097C126322002 @default.
- W4376867097 hasConceptScore W4376867097C164705383 @default.
- W4376867097 hasConceptScore W4376867097C185592680 @default.
- W4376867097 hasConceptScore W4376867097C192562407 @default.
- W4376867097 hasConceptScore W4376867097C2777714996 @default.
- W4376867097 hasConceptScore W4376867097C2780930700 @default.
- W4376867097 hasConceptScore W4376867097C2780940725 @default.
- W4376867097 hasConceptScore W4376867097C2781244666 @default.
- W4376867097 hasConceptScore W4376867097C48349386 @default.
- W4376867097 hasConceptScore W4376867097C55493867 @default.
- W4376867097 hasConceptScore W4376867097C71924100 @default.