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- W4376867237 abstract "Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response to a CHIKV-like particle-adjuvanted vaccine (PXVX0317) from samples obtained from a phase 2 clinical trial in humans (NCT03483961). Immunization with PXVX0317 induced high levels of neutralizing antibody in serum against CHIKV and circulating antigen-specific B cells up to 6 months after immunization. Monoclonal antibodies (mAbs) generated from peripheral blood B cells of three PXVX0317-vaccinated individuals on day 57 after immunization potently neutralized CHIKV infection, and a subset of these inhibited multiple related arthritogenic alphaviruses. Epitope mapping and cryo-electron microscopy defined two broadly neutralizing mAbs that uniquely bind to the apex of the B domain of the E2 glycoprotein. These results demonstrate the inhibitory breadth and activity of the human B cell response induced by the PXVX0317 vaccine against CHIKV and potentially other related alphaviruses." @default.
- W4376867237 created "2023-05-18" @default.
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- W4376867237 date "2023-05-17" @default.
- W4376867237 modified "2023-10-12" @default.
- W4376867237 title "A chikungunya virus–like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans" @default.
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- W4376867237 doi "https://doi.org/10.1126/scitranslmed.ade8273" @default.
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