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- W4376867462 endingPage "8889" @default.
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- W4376867462 abstract "Abstract Mild cognitive impairment (MCI) is regarded as a transitional stage between normal aging and Alzheimer’s disease. Numerous voxel-based morphometry (VBM) and resting-state fMRI (rs-fMRI) studies have provided strong evidence of abnormalities in the structure and intrinsic function of brain regions in MCI. Studies have recently begun to explore their association but have not employed systematic information in this pursuit. Herein, a multimodal meta-analysis was performed, which included 43 VBM datasets (1,247 patients and 1,352 controls) of gray matter volume (GMV) and 42 rs-fMRI datasets (1,468 patients and 1,605 controls) that combined 3 metrics: amplitude of low-frequency fluctuation, the fractional amplitude of low-frequency fluctuation, and regional homogeneity. Compared to controls, patients with MCI displayed convergent reduced regional GMV and altered intrinsic activity, mainly in the default mode network and salience network. Decreased GMV alone in ventral medial prefrontal cortex and altered intrinsic function alone in bilateral dorsal anterior cingulate/paracingulate gyri, right lingual gyrus, and cerebellum were identified, respectively. This meta-analysis investigated complex patterns of convergent and distinct brain alterations impacting different neural networks in MCI patients, which contributes to a further understanding of the pathophysiology of MCI." @default.
- W4376867462 created "2023-05-18" @default.
- W4376867462 creator A5002237952 @default.
- W4376867462 creator A5006893756 @default.
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- W4376867462 creator A5051538064 @default.
- W4376867462 creator A5058853115 @default.
- W4376867462 date "2023-05-17" @default.
- W4376867462 modified "2023-10-15" @default.
- W4376867462 title "Convergent and distinct neural structural and functional patterns of mild cognitive impairment: a multimodal meta-analysis" @default.
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