FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376867533> ?p ?o ?g. }

• W4376867533 endingPage "E20" @default.
• W4376867533 startingPage "E10" @default.
• W4376867533 abstract "Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. Although dozens of preclinical models have been developed to recapitulate stages of MAFLD, few achieve fibrosis using an experimental design that mimics human pathogenesis. We sought to clarify whether the combination of thermoneutral (TN) housing and consumption of a classical Western diet (WD) would accelerate the onset and progression of MAFLD. Male and female C57Bl/6J mice were fed a nutrient-matched low-fat control or Western diet (WD) for 16 wk. Mice were housed with littermates at either standard temperature (TS; 22°C) or thermoneutral-like conditions (TN; ∼29°C). Male, but not female, mice housed at TN and fed a WD were significantly heavier than TS-housed control animals. WD-fed mice housed under TN conditions had lower levels of circulating glucose compared with TS mice; however, there were select but minimal differences in other circulating markers. Although WD-fed TN males had higher liver enzyme and higher liver triglyceride levels, no differences in markers of liver injury or hepatic lipid accumulation were observed in females. Housing temperature had little effect on histopathological scoring of MAFLD progression in males; however, although female mice retained a level of protection, WD-TN conditions trended toward a worsened hepatic phenotype, which was associated with higher macrophage transcript expression and content. Our results indicate that interventions coupling TN housing and WD-induced MAFLD should be longer than 16 wk to accelerate hepatic steatosis and increase inflammation in both sexes of mice.NEW & NOTEWORTHY Mouse models leading to accelerated fatty liver onset are a useful translational tool. Here we show that coupling thermoneutral-like housing and Western diet feeding in mice for 16 wk does not lead to significant disease progression in either sex, though the molecular phenotype indicates priming of immune-related and fibrotic pathways." @default.
• W4376867533 created "2023-05-18" @default.
• W4376867533 creator A5001695966 @default.
• W4376867533 creator A5011057218 @default.
• W4376867533 creator A5017127515 @default.
• W4376867533 creator A5024168823 @default.
• W4376867533 creator A5033087712 @default.
• W4376867533 creator A5051847980 @default.
• W4376867533 creator A5052748892 @default.
• W4376867533 creator A5076466872 @default.
• W4376867533 creator A5083997128 @default.
• W4376867533 creator A5086957322 @default.
• W4376867533 date "2023-07-01" @default.
• W4376867533 modified "2023-09-26" @default.
• W4376867533 title "Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female C57Bl/6J mice fed a Western diet" @default.
• W4376867533 cites W1594187709 @default.
• W4376867533 cites W1836201035 @default.
• W4376867533 cites W2004035484 @default.
• W4376867533 cites W2005666028 @default.
• W4376867533 cites W2035970641 @default.
• W4376867533 cites W2068053039 @default.
• W4376867533 cites W2077720183 @default.
• W4376867533 cites W2107277218 @default.
• W4376867533 cites W2115573976 @default.
• W4376867533 cites W2128157888 @default.
• W4376867533 cites W2152311269 @default.
• W4376867533 cites W2236056553 @default.
• W4376867533 cites W2334890493 @default.
• W4376867533 cites W2415876542 @default.
• W4376867533 cites W2521110133 @default.
• W4376867533 cites W2611378632 @default.
• W4376867533 cites W2626648542 @default.
• W4376867533 cites W2744982526 @default.
• W4376867533 cites W2765945674 @default.
• W4376867533 cites W2767116475 @default.
• W4376867533 cites W2804179281 @default.
• W4376867533 cites W2891877843 @default.
• W4376867533 cites W2897934013 @default.
• W4376867533 cites W2899389750 @default.
• W4376867533 cites W2901814223 @default.
• W4376867533 cites W2914710045 @default.
• W4376867533 cites W2917938593 @default.
• W4376867533 cites W2935232468 @default.
• W4376867533 cites W2968872536 @default.
• W4376867533 cites W3004644667 @default.
• W4376867533 cites W3005585888 @default.
• W4376867533 cites W3015656117 @default.
• W4376867533 cites W3082104408 @default.
• W4376867533 cites W3085137158 @default.
• W4376867533 cites W3108612234 @default.
• W4376867533 cites W3118981406 @default.
• W4376867533 cites W3138629243 @default.
• W4376867533 cites W3166645689 @default.
• W4376867533 cites W3199019000 @default.
• W4376867533 cites W3199798706 @default.
• W4376867533 cites W4206950463 @default.
• W4376867533 cites W4281714255 @default.
• W4376867533 cites W4283011943 @default.
• W4376867533 cites W4308684923 @default.
• W4376867533 cites W4313237264 @default.
• W4376867533 cites W4320710220 @default.
• W4376867533 cites W4321253587 @default.
• W4376867533 doi "https://doi.org/10.1152/ajpendo.00124.2023" @default.
• W4376867533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37196059" @default.
• W4376867533 hasPublicationYear "2023" @default.
• W4376867533 type Work @default.
• W4376867533 citedByCount "0" @default.
• W4376867533 crossrefType "journal-article" @default.
• W4376867533 hasAuthorship W4376867533A5001695966 @default.
• W4376867533 hasAuthorship W4376867533A5011057218 @default.
• W4376867533 hasAuthorship W4376867533A5017127515 @default.
• W4376867533 hasAuthorship W4376867533A5024168823 @default.
• W4376867533 hasAuthorship W4376867533A5033087712 @default.
• W4376867533 hasAuthorship W4376867533A5051847980 @default.
• W4376867533 hasAuthorship W4376867533A5052748892 @default.
• W4376867533 hasAuthorship W4376867533A5076466872 @default.
• W4376867533 hasAuthorship W4376867533A5083997128 @default.
• W4376867533 hasAuthorship W4376867533A5086957322 @default.
• W4376867533 hasConcept C126322002 @default.
• W4376867533 hasConcept C134018914 @default.
• W4376867533 hasConcept C2776175330 @default.
• W4376867533 hasConcept C2776637226 @default.
• W4376867533 hasConcept C2776914184 @default.
• W4376867533 hasConcept C2778163477 @default.
• W4376867533 hasConcept C2778772119 @default.
• W4376867533 hasConcept C2778913445 @default.
• W4376867533 hasConcept C2779134260 @default.
• W4376867533 hasConcept C2780559512 @default.
• W4376867533 hasConcept C2780942790 @default.
• W4376867533 hasConcept C71924100 @default.
• W4376867533 hasConcept C86803240 @default.
• W4376867533 hasConceptScore W4376867533C126322002 @default.
• W4376867533 hasConceptScore W4376867533C134018914 @default.
• W4376867533 hasConceptScore W4376867533C2776175330 @default.
• W4376867533 hasConceptScore W4376867533C2776637226 @default.
• W4376867533 hasConceptScore W4376867533C2776914184 @default.
• W4376867533 hasConceptScore W4376867533C2778163477 @default.
• W4376867533 hasConceptScore W4376867533C2778772119 @default.

• next