FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376867586> ?p ?o ?g. }

• W4376867586 endingPage "e1011158" @default.
• W4376867586 startingPage "e1011158" @default.
• W4376867586 abstract "The pathogenic yeast Pichia kudriavzevii , previously known as Candida krusei , is more distantly related to Candida albicans than clinically relevant CTG-clade Candida species. Its cell wall, a dynamic organelle that is the first point of interaction between pathogen and host, is relatively understudied, and its wall proteome remains unidentified to date. Here, we present an integrated study of the cell wall in P . kudriavzevii . Our comparative genomic studies and experimental data indicate that the general structure of the cell wall in P . kudriavzevii is similar to Saccharomyces cerevisiae and C . albicans and is comprised of β-1,3-glucan, β-1,6-glucan, chitin, and mannoproteins. However, some pronounced differences with C . albicans walls were observed, for instance, higher mannan and protein levels and altered protein mannosylation patterns. Further, despite absence of proteins with high sequence similarity to Candida adhesins, protein structure modeling identified eleven proteins related to flocculins/adhesins in S . cerevisiae or C . albicans . To obtain a proteomic comparison of biofilm and planktonic cells, P . kudriavzevii cells were grown to exponential phase and in static 24-h cultures. Interestingly, the 24-h static cultures of P . kudriavzevii yielded formation of floating biofilm (flor) rather than adherence to polystyrene at the bottom. The proteomic analysis of both conditions identified a total of 33 cell wall proteins. In line with a possible role in flor formation, increased abundance of flocculins, in particular Flo110, was observed in the floating biofilm compared to exponential cells. This study is the first to provide a detailed description of the cell wall in P . kudriavzevii including its cell wall proteome, and paves the way for further investigations on the importance of flor formation and flocculins in the pathogenesis of P . kudriavzevii ." @default.
• W4376867586 created "2023-05-18" @default.
• W4376867586 creator A5003501872 @default.
• W4376867586 creator A5003559714 @default.
• W4376867586 creator A5008454170 @default.
• W4376867586 creator A5010968169 @default.
• W4376867586 creator A5017331599 @default.
• W4376867586 creator A5028961010 @default.
• W4376867586 creator A5078837579 @default.
• W4376867586 creator A5082174904 @default.
• W4376867586 date "2023-05-17" @default.
• W4376867586 modified "2023-10-18" @default.
• W4376867586 title "Integrated post-genomic cell wall analysis reveals floating biofilm formation associated with high expression of flocculins in the pathogen Pichia kudriavzevii" @default.
• W4376867586 cites W1536320539 @default.
• W4376867586 cites W1737498497 @default.
• W4376867586 cites W1964900779 @default.
• W4376867586 cites W1991488616 @default.
• W4376867586 cites W1993370685 @default.
• W4376867586 cites W1995203663 @default.
• W4376867586 cites W1995707690 @default.
• W4376867586 cites W1996677209 @default.
• W4376867586 cites W2009633046 @default.
• W4376867586 cites W2011992120 @default.
• W4376867586 cites W2012150744 @default.
• W4376867586 cites W2025805745 @default.
• W4376867586 cites W2029662163 @default.
• W4376867586 cites W2034546933 @default.
• W4376867586 cites W2040556195 @default.
• W4376867586 cites W2040773127 @default.
• W4376867586 cites W2053195919 @default.
• W4376867586 cites W2055097603 @default.
• W4376867586 cites W2062589993 @default.
• W4376867586 cites W2064059521 @default.
• W4376867586 cites W2067631595 @default.
• W4376867586 cites W2077434528 @default.
• W4376867586 cites W2080425942 @default.
• W4376867586 cites W2090475156 @default.
• W4376867586 cites W2093370585 @default.
• W4376867586 cites W2094285298 @default.
• W4376867586 cites W2094725612 @default.
• W4376867586 cites W2094831794 @default.
• W4376867586 cites W2096857575 @default.
• W4376867586 cites W2097700671 @default.
• W4376867586 cites W2099509134 @default.
• W4376867586 cites W2101877292 @default.
• W4376867586 cites W2102496935 @default.
• W4376867586 cites W2105164237 @default.
• W4376867586 cites W2106387328 @default.
• W4376867586 cites W2106860332 @default.
• W4376867586 cites W2117903782 @default.
• W4376867586 cites W2128291007 @default.
• W4376867586 cites W2129062885 @default.
• W4376867586 cites W2130963153 @default.
• W4376867586 cites W2134023938 @default.
• W4376867586 cites W2137959581 @default.
• W4376867586 cites W2138145776 @default.
• W4376867586 cites W2141294282 @default.
• W4376867586 cites W2144998676 @default.
• W4376867586 cites W2145659845 @default.
• W4376867586 cites W2147689337 @default.
• W4376867586 cites W2151665495 @default.
• W4376867586 cites W2154592170 @default.
• W4376867586 cites W2155403267 @default.
• W4376867586 cites W2158351657 @default.
• W4376867586 cites W2161408515 @default.
• W4376867586 cites W2167936486 @default.
• W4376867586 cites W2169540909 @default.
• W4376867586 cites W2265623652 @default.
• W4376867586 cites W2286053179 @default.
• W4376867586 cites W2564991918 @default.
• W4376867586 cites W2806093302 @default.
• W4376867586 cites W2884825609 @default.
• W4376867586 cites W2905084100 @default.
• W4376867586 cites W2926202803 @default.
• W4376867586 cites W2949683836 @default.
• W4376867586 cites W2990346134 @default.
• W4376867586 cites W3003287532 @default.
• W4376867586 cites W3008280539 @default.
• W4376867586 cites W3035089792 @default.
• W4376867586 cites W3043130611 @default.
• W4376867586 cites W3092496955 @default.
• W4376867586 cites W3137069977 @default.
• W4376867586 cites W3153784842 @default.
• W4376867586 cites W3210105333 @default.
• W4376867586 cites W3217504160 @default.
• W4376867586 cites W4200047626 @default.
• W4376867586 cites W4211178015 @default.
• W4376867586 cites W4231537275 @default.
• W4376867586 cites W4281790889 @default.
• W4376867586 cites W4303684539 @default.
• W4376867586 doi "https://doi.org/10.1371/journal.ppat.1011158" @default.
• W4376867586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37196016" @default.
• W4376867586 hasPublicationYear "2023" @default.
• W4376867586 type Work @default.
• W4376867586 citedByCount "0" @default.
• W4376867586 crossrefType "journal-article" @default.
• W4376867586 hasAuthorship W4376867586A5003501872 @default.
• W4376867586 hasAuthorship W4376867586A5003559714 @default.

• next