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• W4376871660 endingPage "186" @default.
• W4376871660 startingPage "131" @default.
• W4376871660 abstract "Precision medicine uses innovative approaches to improve disease prevention and treatment outcomes by taking into account people’s genetic backgrounds, environments, and lifestyles. Treatment of depression is particularly challenging, given that 30–50% of patients do not respond adequately to antidepressants, while those who respond may experience unpleasant adverse drug reactions (ADRs) that decrease their quality of life and compliance. This chapter aims to present the available scientific data that focus on the impact of genetic variants on the efficacy and toxicity of antidepressants. We compiled data from candidate gene and genome-wide association studies that investigated associations between pharmacodynamic and pharmacokinetic genes and response to antidepressants regarding symptom improvement and ADRs. We also summarized the existing pharmacogenetic-based treatment guidelines for antidepressants, used to guide the selection of the right antidepressant and its dose based on the patient's genetic profile, aiming to achieve maximum efficacy and minimum toxicity. Finally, we reviewed the clinical implementation of pharmacogenomics studies focusing on patients on antidepressants. The available data demonstrate that precision medicine can increase the efficacy of antidepressants and reduce the occurrence of ADRs and ultimately improve patients’ quality of life." @default.
• W4376871660 created "2023-05-18" @default.
• W4376871660 creator A5022636484 @default.
• W4376871660 creator A5028791127 @default.
• W4376871660 creator A5068534236 @default.
• W4376871660 date "2023-01-01" @default.
• W4376871660 modified "2023-09-26" @default.
• W4376871660 title "Precision Medicine in Antidepressants Treatment" @default.
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