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- W4376873154 abstract "In Brief The authors report a rare case of orbital sarcoidosis with caseating granulomatous inflammation. A 55-year-old man presented with a 2-month history of progressively worsening diplopia and proptosis of the OS. Orbital CT demonstrated a diffuse orbital mass. Diagnostic anterior orbitotomy demonstrated caseating granulomas. Infectious testing, including special stains, cultures, and polymerase chain reaction testing, were negative for infectious causes. Chest CT demonstrated the presence of hilar lymphadenopathy with bronchoscopic biopsy showing noncaseating granulomas, supporting a diagnosis of sarcoidosis. The patient achieved clinical and symptomatic improvement at 8-month follow-up on methotrexate. While sarcoidosis is typically characterized by non-necrotizing granulomatous inflammation, sarcoid granulomas with necrosis have been previously described in pulmonary histopathology. This case emphasizes the importance of a comprehensive systemic workup, keeping systemic sarcoidosis on the differential, for necrotizing granulomatous inflammation of the orbit. Precis: We report a rare case of orbital sarcoidosis characterized by caseating granulomatous inflammation. This case demonstrates that systemic sarcoidosis should remain on the differential for necrotizing granulomatous inflammation of the orbit." @default.
- W4376873154 created "2023-05-18" @default.
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- W4376873154 date "2023-05-16" @default.
- W4376873154 modified "2023-09-27" @default.
- W4376873154 title "A Case of Orbital Sarcoidosis with Caseating Granulomatous Inflammation" @default.
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- W4376873154 doi "https://doi.org/10.1097/iop.0000000000002422" @default.
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