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- W4376874257 abstract "The coronavirus SARS-CoV-2 is the causative agent for the COVID-19 pandemic. Its proteome is typically separated into three classes of proteins: (1) Structural proteins which facilitate the transport and host cell infiltration of the viral RNA, (2) non-structural proteins which are thought to be essential for the viral life cycle and are all produced from open reading frame 1ab (ORF1ab) on the RNA, and (3) everything else, called accessory proteins. Although it was originally thought that these accessory proteins are non-essential for viral replication, a growing body of evidence suggests that these diverse proteins have crucial roles in virus-host interactions, in particular in the way they interfere with the signalling pathways that modulate the host cell’s response to infection and viral pathogenicity. Here, we summarize efforts to structurally characterize the accessory proteins from SARS-CoV-2." @default.
- W4376874257 created "2023-05-18" @default.
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- W4376874257 date "2023-01-02" @default.
- W4376874257 modified "2023-10-01" @default.
- W4376874257 title "Structural biology of SARS-CoV-2 accessory proteins" @default.
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- W4376874257 doi "https://doi.org/10.1080/0889311x.2023.2173744" @default.
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