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• W4376875178 endingPage "8878" @default.
• W4376875178 startingPage "8878" @default.
• W4376875178 abstract "The majority of epidermal growth factor receptor (EGFR) mutations (85-90%) are exon 19 deletions and L858R point mutations of exon 21, characterized by high sensitivity to EGFR-tyrosine kinase inhibitors (TKIs). Less is known about uncommon mutations (10-15% of EGFR mutations). The predominant mutation types in this category include exon 18 point mutations, exon 21 L861X, exon 20 insertions, and exon 20 S768I. This group shows a heterogeneous prevalence, partly due to different testing methods and to the presence of compound mutations, which in some cases can lead to shorter overall survival and different sensitivity to different TKIs compared to simple mutations. Additionally, EGFR-TKI sensitivity may also vary depending on the specific mutation and the tertiary structure of the protein. The best strategy remains uncertain, and the data of EGFR-TKIs efficacy are based on few prospective and some retrospective series. Newer investigational agents are still under study, and there are no other approved specific treatments targeting uncommon EGFR mutations. Defining the best treatment option for this patient population remains an unmet medical need. The objective of this review is to evaluate existing data on the outcomes, epidemiology, and clinical characteristics of lung cancer patients with rare EGFR mutations, with a focus on intracranial activity and response to immunotherapy." @default.
• W4376875178 created "2023-05-18" @default.
• W4376875178 creator A5004618771 @default.
• W4376875178 creator A5057753126 @default.
• W4376875178 creator A5059144188 @default.
• W4376875178 creator A5089022719 @default.
• W4376875178 creator A5091150576 @default.
• W4376875178 date "2023-05-17" @default.
• W4376875178 modified "2023-10-01" @default.
• W4376875178 title "Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need" @default.
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