Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376875537> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4376875537 abstract "ABSTRACT Stenotrophomonas maltophilia , an emerging multidrug-resistant opportunistic bacterium in humans is of major concern for immunocompromised individuals for causing pneumonia and bloodborne infections. This bacterial pathogen is associated with a considerable fatality/case ratio, with up to 100%, when presented as hemorrhagic fever. It is resistant to commonly used drugs as well as to antibiotic combinations. In-silico based functional network analysis is a key approach to get novel insights into virulence and resistance in pathogenic organisms. This study included the protein-protein interaction (PPI) network analysis of 150 specific genes identified for antibiotic resistance mechanism and virulence pathways. Eight proteins, namely, pilL , fliA , Smlt2260 , Smlt2267 , cheW , Smlt2318 , cheZ , and fliM were identified as hub proteins. Further docking studies of selected phytochemicals were performed against the identified hub proteins. Deoxytubulosine and Corosolic acid were found to be potent inhibitors of hub proteins of pathogenic S. maltophilia based on protein-ligand interactive study. Further pharmacophore studies are warranted with these molecules to develop them as novel antibiotics against S. maltophilia ." @default.
- W4376875537 created "2023-05-18" @default.
- W4376875537 creator A5029349144 @default.
- W4376875537 creator A5048933687 @default.
- W4376875537 creator A5056675012 @default.
- W4376875537 creator A5083403033 @default.
- W4376875537 creator A5089501388 @default.
- W4376875537 date "2023-05-16" @default.
- W4376875537 modified "2023-09-26" @default.
- W4376875537 title "Functional network analysis identifies multiple virulence and antibiotic resistance systems in<i>Stenotrophomonas maltophilia</i>" @default.
- W4376875537 cites W1887624773 @default.
- W4376875537 cites W1923009507 @default.
- W4376875537 cites W1932003991 @default.
- W4376875537 cites W1991289444 @default.
- W4376875537 cites W1994780970 @default.
- W4376875537 cites W2090581372 @default.
- W4376875537 cites W2101996554 @default.
- W4376875537 cites W2103912979 @default.
- W4376875537 cites W2118904250 @default.
- W4376875537 cites W2145958601 @default.
- W4376875537 cites W2155246554 @default.
- W4376875537 cites W2155317724 @default.
- W4376875537 cites W2164332468 @default.
- W4376875537 cites W2607233989 @default.
- W4376875537 cites W2609112093 @default.
- W4376875537 cites W2888856643 @default.
- W4376875537 cites W2900102202 @default.
- W4376875537 cites W2982531295 @default.
- W4376875537 cites W2989866748 @default.
- W4376875537 cites W3019232346 @default.
- W4376875537 cites W3143294009 @default.
- W4376875537 cites W3187980261 @default.
- W4376875537 cites W3194188670 @default.
- W4376875537 cites W4220719956 @default.
- W4376875537 cites W4285600441 @default.
- W4376875537 cites W4297050511 @default.
- W4376875537 cites W4311986517 @default.
- W4376875537 doi "https://doi.org/10.1101/2023.05.15.540742" @default.
- W4376875537 hasPublicationYear "2023" @default.
- W4376875537 type Work @default.
- W4376875537 citedByCount "0" @default.
- W4376875537 crossrefType "posted-content" @default.
- W4376875537 hasAuthorship W4376875537A5029349144 @default.
- W4376875537 hasAuthorship W4376875537A5048933687 @default.
- W4376875537 hasAuthorship W4376875537A5056675012 @default.
- W4376875537 hasAuthorship W4376875537A5083403033 @default.
- W4376875537 hasAuthorship W4376875537A5089501388 @default.
- W4376875537 hasBestOaLocation W43768755371 @default.
- W4376875537 hasConcept C104317684 @default.
- W4376875537 hasConcept C2775905019 @default.
- W4376875537 hasConcept C2776352461 @default.
- W4376875537 hasConcept C2776460866 @default.
- W4376875537 hasConcept C2777637488 @default.
- W4376875537 hasConcept C2778883795 @default.
- W4376875537 hasConcept C501593827 @default.
- W4376875537 hasConcept C523546767 @default.
- W4376875537 hasConcept C54355233 @default.
- W4376875537 hasConcept C56173144 @default.
- W4376875537 hasConcept C60644358 @default.
- W4376875537 hasConcept C60987743 @default.
- W4376875537 hasConcept C70721500 @default.
- W4376875537 hasConcept C86803240 @default.
- W4376875537 hasConcept C89423630 @default.
- W4376875537 hasConcept C94665300 @default.
- W4376875537 hasConceptScore W4376875537C104317684 @default.
- W4376875537 hasConceptScore W4376875537C2775905019 @default.
- W4376875537 hasConceptScore W4376875537C2776352461 @default.
- W4376875537 hasConceptScore W4376875537C2776460866 @default.
- W4376875537 hasConceptScore W4376875537C2777637488 @default.
- W4376875537 hasConceptScore W4376875537C2778883795 @default.
- W4376875537 hasConceptScore W4376875537C501593827 @default.
- W4376875537 hasConceptScore W4376875537C523546767 @default.
- W4376875537 hasConceptScore W4376875537C54355233 @default.
- W4376875537 hasConceptScore W4376875537C56173144 @default.
- W4376875537 hasConceptScore W4376875537C60644358 @default.
- W4376875537 hasConceptScore W4376875537C60987743 @default.
- W4376875537 hasConceptScore W4376875537C70721500 @default.
- W4376875537 hasConceptScore W4376875537C86803240 @default.
- W4376875537 hasConceptScore W4376875537C89423630 @default.
- W4376875537 hasConceptScore W4376875537C94665300 @default.
- W4376875537 hasLocation W43768755371 @default.
- W4376875537 hasOpenAccess W4376875537 @default.
- W4376875537 hasPrimaryLocation W43768755371 @default.
- W4376875537 hasRelatedWork W1977571916 @default.
- W4376875537 hasRelatedWork W2223928178 @default.
- W4376875537 hasRelatedWork W2345801705 @default.
- W4376875537 hasRelatedWork W2385515840 @default.
- W4376875537 hasRelatedWork W2387160139 @default.
- W4376875537 hasRelatedWork W2401291924 @default.
- W4376875537 hasRelatedWork W2757528433 @default.
- W4376875537 hasRelatedWork W3093499299 @default.
- W4376875537 hasRelatedWork W4205138535 @default.
- W4376875537 hasRelatedWork W4224987100 @default.
- W4376875537 isParatext "false" @default.
- W4376875537 isRetracted "false" @default.
- W4376875537 workType "article" @default.