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- W4376875557 abstract "Neurodegenerative dementias encompass a clinically, genetically, and pathologically heterogeneous group of conditions characterized by the progressive accumulation of misfolded proteins, and loss of brain structure and physiological function. Despite clinicopathological differences, neurodegenerative dementias have all been associated with increased neuroinflammation, which we suggest plays an etiological role in the onset and progression of these conditions rather than only being a response to neuronal injury. Positron emission tomography with tracers of microglial and astrocytic activation enables the in vivo quantification and localization of neuroinflammation in the brains of people living with dementia. In this chapter, we discuss the evidence that PET inflammation imaging has provided in the context of neurodegenerative dementias, and the potential for its application in clinical trials and practice." @default.
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- W4376875557 date "2023-07-01" @default.
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- W4376875557 title "Top 10 unanswered questions about quality use of medicines in people living with dementia" @default.
- W4376875557 doi "https://doi.org/10.1016/j.sapharm.2023.04.035" @default.
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