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- W4376875592 abstract "In this research work we report the synthesis of a new series of triazene prodrugs designed for Melanocyte-Directed Enzyme Prodrug Therapy (MDEPT). These compounds are derived from the N-acyltyrosine amino acid – a good enzyme substrate for the tyrosinase enzyme, which is significantly overexpressed in melanoma cells. We analysed their chemical stability and plasma enzymatic hydrolysis, and we also evaluated the release of the antitumoral drug in the presence of the tyrosinase. Subsequently, we performed the evaluation of the prodrug cytotoxicity in melanoma cell lines with different levels of tyrosinase activity. Prodrug 5c showed the highest cytotoxicity against melanoma cell lines, and this effect correlated well with the tyrosinase activity suggesting that prodrug cytotoxicity is tyrosinase-dependent." @default.
- W4376875592 created "2023-05-18" @default.
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- W4376875592 date "2023-07-01" @default.
- W4376875592 modified "2023-10-01" @default.
- W4376875592 title "Towards assessment of pharmacy preceptors: a qualitative study of preceptor and preceptee perspectives" @default.
- W4376875592 doi "https://doi.org/10.1016/j.sapharm.2023.04.008" @default.
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