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• W4376875787 abstract "Emerging evidence suggests that brain derived extracellular vesicles (EVs) and particles (EPs) can cross blood-brain barrier and mediate communication among neurons, astrocytes, microglial, and other cells of the central nervous system (CNS). Yet, a complete understanding of the molecular landscape and function of circulating EVs &amp; EPs (EVPs) remain a major gap in knowledge. This is mainly due to the lack of technologies to isolate and separate all EVPs of heterogeneous dimensions and low buoyant density. In this review, we aim to provide a comprehensive understanding of the neurosecretome, including the extracellular vesicles that carry the molecular signature of the brain in both its microenvironment and the systemic circulation. We discuss the biogenesis of EVPs, their function, cell-to-cell communication, past and emerging isolation technologies, therapeutics, and liquid-biopsy applications. It is important to highlight that the landscape of EVPs is in a constant state of evolution; hence, we not only discuss the past literature and current landscape of the EVPs, but we also speculate as to how novel EVPs may contribute to the etiology of addiction, depression, psychiatric, neurodegenerative diseases, and aid in the real time monitoring of the “living brain”. Overall, the neurosecretome is a concept we introduce here to embody the compendium of circulating particles of the brain for their function and disease pathogenesis. Finally, for the purpose of inclusion of all extracellular particles, we have used the term EVPs as defined by the International Society of Extracellular Vesicles (ISEV)." @default.
• W4376875787 created "2023-05-18" @default.
• W4376875787 creator A5022940704 @default.
• W4376875787 creator A5058025480 @default.
• W4376875787 creator A5060877193 @default.
• W4376875787 creator A5077771856 @default.
• W4376875787 date "2023-05-17" @default.
• W4376875787 modified "2023-10-12" @default.
• W4376875787 title "The human neurosecretome: extracellular vesicles and particles (EVPs) of the brain for intercellular communication, therapy, and liquid-biopsy applications" @default.
• W4376875787 cites W141181845 @default.
• W4376875787 cites W1469666119 @default.
• W4376875787 cites W1525194552 @default.
• W4376875787 cites W1542251585 @default.
• W4376875787 cites W1544863932 @default.
• W4376875787 cites W1601663528 @default.
• W4376875787 cites W1601681275 @default.
• W4376875787 cites W1651376769 @default.
• W4376875787 cites W1682077723 @default.
• W4376875787 cites W1867555087 @default.
• W4376875787 cites W1877686344 @default.
• W4376875787 cites W1914453902 @default.
• W4376875787 cites W1967367827 @default.
• W4376875787 cites W1968047901 @default.
• W4376875787 cites W1968821998 @default.
• W4376875787 cites W1969123951 @default.
• W4376875787 cites W1969607893 @default.
• W4376875787 cites W1969738372 @default.
• W4376875787 cites W1971186239 @default.
• W4376875787 cites W1972296893 @default.
• W4376875787 cites W1975689733 @default.
• W4376875787 cites W1975859224 @default.
• W4376875787 cites W1978250223 @default.
• W4376875787 cites W1980269466 @default.
• W4376875787 cites W1980593265 @default.
• W4376875787 cites W1981016513 @default.
• W4376875787 cites W1982280290 @default.
• W4376875787 cites W1982669563 @default.
• W4376875787 cites W1984472621 @default.
• W4376875787 cites W1985619179 @default.
• W4376875787 cites W1986175732 @default.
• W4376875787 cites W1986321004 @default.
• W4376875787 cites W1989090719 @default.
• W4376875787 cites W1990348466 @default.
• W4376875787 cites W1991043452 @default.
• W4376875787 cites W1991390602 @default.
• W4376875787 cites W1995827114 @default.
• W4376875787 cites W1996024251 @default.
• W4376875787 cites W1997728372 @default.
• W4376875787 cites W2003343932 @default.
• W4376875787 cites W2004895989 @default.
• W4376875787 cites W2007047564 @default.
• W4376875787 cites W2007499410 @default.
• W4376875787 cites W2008565079 @default.
• W4376875787 cites W2009649000 @default.
• W4376875787 cites W2012624148 @default.
• W4376875787 cites W2012643031 @default.
• W4376875787 cites W2013907149 @default.
• W4376875787 cites W2015805487 @default.
• W4376875787 cites W2019892195 @default.
• W4376875787 cites W2024357833 @default.
• W4376875787 cites W2025199750 @default.
• W4376875787 cites W2027195751 @default.
• W4376875787 cites W2030701238 @default.
• W4376875787 cites W2031163840 @default.
• W4376875787 cites W2031323283 @default.
• W4376875787 cites W2042060958 @default.
• W4376875787 cites W2043946753 @default.
• W4376875787 cites W2047159195 @default.
• W4376875787 cites W2049900264 @default.
• W4376875787 cites W2051090856 @default.
• W4376875787 cites W2052853635 @default.
• W4376875787 cites W2053540444 @default.
• W4376875787 cites W2055313665 @default.
• W4376875787 cites W2055665132 @default.
• W4376875787 cites W2056094172 @default.
• W4376875787 cites W2058815861 @default.
• W4376875787 cites W2065502974 @default.
• W4376875787 cites W2066432115 @default.
• W4376875787 cites W2067013656 @default.
• W4376875787 cites W2067267561 @default.
• W4376875787 cites W2067646697 @default.
• W4376875787 cites W2069437848 @default.
• W4376875787 cites W2071188263 @default.
• W4376875787 cites W2076722895 @default.
• W4376875787 cites W2077047479 @default.
• W4376875787 cites W2077548177 @default.
• W4376875787 cites W2080418767 @default.
• W4376875787 cites W2080937840 @default.
• W4376875787 cites W2082798838 @default.
• W4376875787 cites W2086275775 @default.
• W4376875787 cites W2086612059 @default.
• W4376875787 cites W2090175640 @default.
• W4376875787 cites W2090926836 @default.
• W4376875787 cites W2092651201 @default.
• W4376875787 cites W2095524365 @default.
• W4376875787 cites W2098259366 @default.
• W4376875787 cites W2101434902 @default.
• W4376875787 cites W2102161788 @default.
• W4376875787 cites W2103433150 @default.
• W4376875787 cites W2108176354 @default.

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