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• W4376876220 abstract "Abstract Several studies have shown a potential protective role of long pentraxin 3 (PTX3) in different lung pathologies. In the present study, we have explored the influence of PTX3 in the bleomycin (BLM)-induced murine model of Idiopathic Pulmonary Fibrosis (IPF). We made a picture of the pulmonary microenvironment by looking at inflammatory infiltrate (macrophages, mast cells, T cells) and stemness/regenerative markers of lung epithelium (SOX2) and fibroblasts/myofibroblasts (CD44) at different time points that retrace the progression of the disease from onset at day 14, to full-blown disease at day 21, to incomplete regression at day 28. We took advantage of transgenic PTX3 overexpressing mice (Tie2-PTX3) and Ptx3 null ones (PTX3-KO) in which IPF was indued. Our data have shown that: throughout the whole experimental period, the CD68 + and CD163 + macrophages and the Tryptase + mast cells are reduced in the Tie2-PTX3 pulmonary microenvironment compared to wild-type (WT) or PTX3-KO; on the contrary, CD4 + T cells are consistently present on day 14 and dramatically decreased on day 21 in Tie2-PTX3 compared to WT or PTX3-KO; CD8 + T cells do not show significant differences on day 14, but are significantly reduced on day 21 in Tie2-PTX3 compared to WT or PTX3-KO; SOX2 is reduced on days 14 and 21 in Tie2-PTX3 compared to WT or PTX3-KO; CD44 is reduced on day 21 in Tie2-PTX3 compared to WT or PTX3-KO. This scenario demonstrates the anti-inflammatory effects of PTX3, which reduces pro-inflammatory cells and counteracts profibrotic events." @default.
• W4376876220 created "2023-05-18" @default.
• W4376876220 creator A5013367044 @default.
• W4376876220 creator A5027847615 @default.
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• W4376876220 creator A5085488541 @default.
• W4376876220 creator A5085737236 @default.
• W4376876220 date "2023-05-17" @default.
• W4376876220 modified "2023-10-14" @default.
• W4376876220 title "PTX3 regulates immune infiltration and epithelial/fibroblast repair and regeneration in idiopathic pulmonary fibrosis" @default.
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• W4376876220 doi "https://doi.org/10.21203/rs.3.rs-2928010/v1" @default.

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