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• W4376880536 abstract "Cytokine imbalance is an important feature in the occurrence and outcome of hepatitis B virus (HBV). Single nucleotide polymorphisms (SNPs) within cytokine genes may affect the protein expression and eventually contribute to the susceptibility of HBV infection. The association between interleukin (IL)-12, IL-17, or IL-21 and the risk of HBV infection has been extensively studied, but yielding equivocal results. The aim of this meta-analysis was to determine the impact of SNPs in IL-12, IL-17, and IL-21 on the risk of HBV infection. We retrieved studies evaluating whether SNPs in IL-12, IL-17, and IL-21 influenced HBV infection from electronic databases, including PUBMED, Web of Science, EBOCO, OVID, and Embase. Summarized odds ratios (ORs) and confidence intervals (CIs) were calculated using STATA software. Under a homozygous comparison, the IL-12A rs568408 was associated with an increased risk of HBV infection in both overall analysis (OR = 1.68, 95% CI, 1.12–2.53) and Caucasians (OR = 1.80, 95% CI, 1.14–2.84). Under a dominant genetic model, the similarly higher risk was also observed in overall analysis (OR = 3.62, 95% CI, 3.08–4.24), Caucasians (OR = 3.29, 95% CI, 2.67–4.05), high-quality studies (OR = 3.29, 95% CI, 2.61–4.14), and low-quality studies (OR = 3.95, 95% CI, 3.17–4.93). Although no significant association was observed between IL-17A rs2275913 and the risk of HBV infection in overall comparison, subgroup analysis revealed that the IL-17A rs2275913 AA genotype was associated with a reduced risk in Asians (OR = 0.72, 95% CI, 0.57–0.91) and high-quality studies (OR = 0.71, 95% CI, 0.55–0.92). However, no significant association of IL12B rs3212227, IL-17A rs2275913, IL-21 rs2221903, and rs907715 with HBV infection was observed. In conclusion, we provide evidence that IL-12A rs568408 was associated with an increased risk of HBV infection and IL-17A rs2275913 AA genotype was a protective factor against HBV infection in Asians." @default.
• W4376880536 created "2023-05-18" @default.
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• W4376880536 date "2023-05-01" @default.
• W4376880536 modified "2023-10-17" @default.
• W4376880536 title "A Meta-Analysis of the Association Between Genetic Polymorphisms in <i>IL-12</i>, <i>IL-17</i>, and <i>IL-21</i> and Risk of Hepatitis B Virus Infection" @default.
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• W4376880536 doi "https://doi.org/10.1089/jir.2022.0249" @default.
• W4376880536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37195820" @default.
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