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- W4376880735 abstract "Introduction: Multidrug resistance organisms have become a great concern globally. Ceftazidime-avibactam (CAZ/AVI) has a broad-spectrum activity against Ambler molecular Class A (narrow-spectrum & extended-spectrum beta-lactamases (ESBLs), serine carbapenemase including KPC). It also has activity against some Class C (KPC) and Class D carbapenemase including OXA-48-like enzymes in Enterobacteriaceae. The study aims to identify clinically relevant sy Aim: nergy between CAZ/AVI+Aztreonam (ATM) for multidrug resistant isolates (MDR) using E-test/disc method. A total of 60 non- Material & Methods: duplicate clinical isolates of different clinical specimens (blood, pus, sputum, urine, and sterile body uids) were collected prospectively over 3- month period (January – March 2022). Antimicrobial susceptibility determined by Kirby-Bauer disc diffusion method. CAZ/AVI+ATM synergy was determined using E- test/disc method. NMIC 500 BD phoenix automated system conrmed the presence of class of enzymes. Of Results: the 60 MDR isolates, Klebsiella (n=35; 58.3%) was the most common followed by E. coli (n=17; 28.3%). CAZ/AVI was susceptible for 25% (n= 15) of the isolates and the remaining 45(75%) were resistant. CLSI guidelines used for interpretation. Using qualitative E-test/disc diffusion method, addition of aztreonam to CAZ/AVI showed susceptibility for 66% (n=30/45) of CAZ/AVI resistant isolates demonstrating a Reverse D synergy. The remaining 15 (out of 45) isolates showed resistance to the above combination and thereby showing no synergy. The most common class of enzymes were Class D (n=25/60) followed by Class B (n=19/60). In screening for CZA Conclusion: /AVI +ATM synergy, the E-test/disc method provides a quick and practical approach for the real world screening and for the targeted use in the patients. This approach would be more relevant considering NDM and its coproduction prevalence is on the rise with limited antibiotic options for such infections." @default.
- W4376880735 created "2023-05-18" @default.
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- W4376880735 date "2023-04-01" @default.
- W4376880735 modified "2023-09-30" @default.
- W4376880735 title "ASSESSING PHENOTYPIC SYNERGISTIC ACTIVITY OF CEFTAZIDIMEAVIBACTAM AND AZTREONAM AGAINST CARBAPENEMASE PRODUCING MULTIDRUG RESISTANT GRAM-NEGATIVE ORGANISMS IN A TERTIARY CARE HOSPITAL, NAVI MUMBAI." @default.
- W4376880735 doi "https://doi.org/10.36106/ijar/9009060" @default.
- W4376880735 hasPublicationYear "2023" @default.
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