Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376958524> ?p ?o ?g. }
- W4376958524 endingPage "216" @default.
- W4376958524 startingPage "209" @default.
- W4376958524 abstract "To date, hypolipidemic drugs of the statin group are among the most popular therapeutic agents used for the prevention and treatment of the most common worldwide atherosclerotic cardiovascular diseases (CVD). Therefore, considerable attention of researchers is focused on statins to study the additional effects of these drugs, which is accompanied by the discovery of new mechanisms of action and properties that should be taken into account to optimize the tactics of managing patients with CVD. In addition to the key lipid-lowering effect of statins associated with the inhibition of the ratelimiting enzyme (3-hydroxy-3-methylglutaryl-coenzyme A reductase), researchers report a variety of other properties of these drugs. Important circumstances contributing to the disclosure of new effects of statins are: improvement of research methods, and first of all, their sensitivity and specificity; the discovery of new molecules and molecular pathways that may be affected by statins. In general, the currently established numerous non-lipid effects of statin drugs can be divided into two groups: favorable and side effects, which must be taken into account when managing patients with CVD and comorbid diseases. Thanks to recent studies using modern clinical diagnostic cardiomarkers (highly sensitive cardiac troponins (CT)), molecular genetic and morphological methods, potential cardiotoxic properties of statin group drugs have been identified. Of particular concern are the data on a statininduced increase in the concentration of highly sensitive CT, which are a key and generally recognized criterion for myocardial damage. In this article we discuss possible mechanisms of increasing the concentration of CT and cardiotoxic effects when using statins." @default.
- W4376958524 created "2023-05-18" @default.
- W4376958524 creator A5056638295 @default.
- W4376958524 creator A5059294927 @default.
- W4376958524 date "2023-04-28" @default.
- W4376958524 modified "2023-09-27" @default.
- W4376958524 title "Statins and highly sensitive cardiac troponins: cardiotoxicity or cross-reactivity?" @default.
- W4376958524 cites W1964235198 @default.
- W4376958524 cites W1974744445 @default.
- W4376958524 cites W1987137066 @default.
- W4376958524 cites W2067020827 @default.
- W4376958524 cites W2073245503 @default.
- W4376958524 cites W2087351164 @default.
- W4376958524 cites W2109828316 @default.
- W4376958524 cites W2120445357 @default.
- W4376958524 cites W2138019079 @default.
- W4376958524 cites W2151836226 @default.
- W4376958524 cites W2167228964 @default.
- W4376958524 cites W2185401965 @default.
- W4376958524 cites W2250152456 @default.
- W4376958524 cites W2285368761 @default.
- W4376958524 cites W2410333440 @default.
- W4376958524 cites W2517162981 @default.
- W4376958524 cites W2579473004 @default.
- W4376958524 cites W2734681774 @default.
- W4376958524 cites W2736141173 @default.
- W4376958524 cites W2765534482 @default.
- W4376958524 cites W2795857347 @default.
- W4376958524 cites W2803196379 @default.
- W4376958524 cites W2813782802 @default.
- W4376958524 cites W2887200251 @default.
- W4376958524 cites W2887236440 @default.
- W4376958524 cites W2888841559 @default.
- W4376958524 cites W2896728005 @default.
- W4376958524 cites W2904459005 @default.
- W4376958524 cites W2910259370 @default.
- W4376958524 cites W2936665015 @default.
- W4376958524 cites W2996335591 @default.
- W4376958524 cites W2997299229 @default.
- W4376958524 cites W3004938650 @default.
- W4376958524 cites W3022069554 @default.
- W4376958524 cites W3082030579 @default.
- W4376958524 cites W3086371537 @default.
- W4376958524 cites W3088158268 @default.
- W4376958524 cites W3113514141 @default.
- W4376958524 cites W3127660071 @default.
- W4376958524 cites W3150628068 @default.
- W4376958524 cites W3198474179 @default.
- W4376958524 cites W4206684355 @default.
- W4376958524 cites W4220986657 @default.
- W4376958524 cites W4283026541 @default.
- W4376958524 cites W4285794997 @default.
- W4376958524 cites W4296617375 @default.
- W4376958524 doi "https://doi.org/10.20996/1819-6446-2023-04-01" @default.
- W4376958524 hasPublicationYear "2023" @default.
- W4376958524 type Work @default.
- W4376958524 citedByCount "0" @default.
- W4376958524 crossrefType "journal-article" @default.
- W4376958524 hasAuthorship W4376958524A5056638295 @default.
- W4376958524 hasAuthorship W4376958524A5059294927 @default.
- W4376958524 hasBestOaLocation W43769585241 @default.
- W4376958524 hasConcept C126322002 @default.
- W4376958524 hasConcept C177713679 @default.
- W4376958524 hasConcept C2776839432 @default.
- W4376958524 hasConcept C2778233292 @default.
- W4376958524 hasConcept C2779134260 @default.
- W4376958524 hasConcept C29730261 @default.
- W4376958524 hasConcept C36036425 @default.
- W4376958524 hasConcept C500558357 @default.
- W4376958524 hasConcept C60644358 @default.
- W4376958524 hasConcept C71924100 @default.
- W4376958524 hasConcept C86803240 @default.
- W4376958524 hasConcept C98274493 @default.
- W4376958524 hasConceptScore W4376958524C126322002 @default.
- W4376958524 hasConceptScore W4376958524C177713679 @default.
- W4376958524 hasConceptScore W4376958524C2776839432 @default.
- W4376958524 hasConceptScore W4376958524C2778233292 @default.
- W4376958524 hasConceptScore W4376958524C2779134260 @default.
- W4376958524 hasConceptScore W4376958524C29730261 @default.
- W4376958524 hasConceptScore W4376958524C36036425 @default.
- W4376958524 hasConceptScore W4376958524C500558357 @default.
- W4376958524 hasConceptScore W4376958524C60644358 @default.
- W4376958524 hasConceptScore W4376958524C71924100 @default.
- W4376958524 hasConceptScore W4376958524C86803240 @default.
- W4376958524 hasConceptScore W4376958524C98274493 @default.
- W4376958524 hasIssue "2" @default.
- W4376958524 hasLocation W43769585241 @default.
- W4376958524 hasOpenAccess W4376958524 @default.
- W4376958524 hasPrimaryLocation W43769585241 @default.
- W4376958524 hasRelatedWork W1983071596 @default.
- W4376958524 hasRelatedWork W2028827500 @default.
- W4376958524 hasRelatedWork W2305100815 @default.
- W4376958524 hasRelatedWork W2403078787 @default.
- W4376958524 hasRelatedWork W2998970160 @default.
- W4376958524 hasRelatedWork W3130188888 @default.
- W4376958524 hasRelatedWork W3195699501 @default.
- W4376958524 hasRelatedWork W4206980680 @default.
- W4376958524 hasRelatedWork W4309737665 @default.