Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377010375> ?p ?o ?g. }
- W4377010375 abstract "Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to targeted drug delivery that emerged in the past decades, more precise therapeutic efficacy is realized in specific pathological sites of clinical diseases. As a highly pyknotic mineralized tissue with lessened blood flow, bone is characterized by a complex remodeling and homeostatic regulation mechanism, which makes drug therapy for skeletal diseases more challenging than other tissues. Bone-targeted therapy has been considered a promising therapeutic approach for handling such drawbacks. With the deepening understanding of bone biology, improvements in some established bone-targeted drugs and novel therapeutic targets for drugs and deliveries have emerged on the horizon. In this review, we provide a panoramic summary of recent advances in therapeutic strategies based on bone targeting. We highlight targeting strategies based on bone structure and remodeling biology. For bone-targeted therapeutic agents, in addition to improvements of the classic denosumab, romosozumab, and PTH1R ligands, potential regulation of the remodeling process targeting other key membrane expressions, cellular crosstalk, and gene expression, of all bone cells has been exploited. For bone-targeted drug delivery, different delivery strategies targeting bone matrix, bone marrow, and specific bone cells are summarized with a comparison between different targeting ligands. Ultimately, this review will summarize recent advances in the clinical translation of bone-targeted therapies and provide a perspective on the challenges for the application of bone-targeted therapy in the clinic and future trends in this area." @default.
- W4377010375 created "2023-05-19" @default.
- W4377010375 creator A5006818041 @default.
- W4377010375 creator A5007868179 @default.
- W4377010375 creator A5018961636 @default.
- W4377010375 creator A5021687717 @default.
- W4377010375 creator A5034071094 @default.
- W4377010375 creator A5042318166 @default.
- W4377010375 creator A5049167024 @default.
- W4377010375 creator A5063626741 @default.
- W4377010375 creator A5087174811 @default.
- W4377010375 date "2023-05-17" @default.
- W4377010375 modified "2023-10-02" @default.
- W4377010375 title "Targeting strategies for bone diseases: signaling pathways and clinical studies" @default.
- W4377010375 cites W138877476 @default.
- W4377010375 cites W1484670766 @default.
- W4377010375 cites W156135897 @default.
- W4377010375 cites W1563493918 @default.
- W4377010375 cites W1571403857 @default.
- W4377010375 cites W1625279067 @default.
- W4377010375 cites W1677973650 @default.
- W4377010375 cites W1686270594 @default.
- W4377010375 cites W1757602702 @default.
- W4377010375 cites W1840439998 @default.
- W4377010375 cites W1840644602 @default.
- W4377010375 cites W1847131470 @default.
- W4377010375 cites W1941304965 @default.
- W4377010375 cites W1956236368 @default.
- W4377010375 cites W1957467225 @default.
- W4377010375 cites W1959454116 @default.
- W4377010375 cites W1965029377 @default.
- W4377010375 cites W1965133822 @default.
- W4377010375 cites W1966233737 @default.
- W4377010375 cites W1966723290 @default.
- W4377010375 cites W1966865004 @default.
- W4377010375 cites W1967506839 @default.
- W4377010375 cites W1968571694 @default.
- W4377010375 cites W1968647565 @default.
- W4377010375 cites W1971365252 @default.
- W4377010375 cites W1972305384 @default.
- W4377010375 cites W1973422437 @default.
- W4377010375 cites W1973433801 @default.
- W4377010375 cites W1975345108 @default.
- W4377010375 cites W1975953388 @default.
- W4377010375 cites W1976041621 @default.
- W4377010375 cites W1976265795 @default.
- W4377010375 cites W1979658752 @default.
- W4377010375 cites W1979686980 @default.
- W4377010375 cites W1979751563 @default.
- W4377010375 cites W1980111231 @default.
- W4377010375 cites W1980471449 @default.
- W4377010375 cites W1980751002 @default.
- W4377010375 cites W1980772641 @default.
- W4377010375 cites W1981284961 @default.
- W4377010375 cites W1982264030 @default.
- W4377010375 cites W1982994807 @default.
- W4377010375 cites W1984208675 @default.
- W4377010375 cites W1984426954 @default.
- W4377010375 cites W1984512053 @default.
- W4377010375 cites W1984821835 @default.
- W4377010375 cites W1984826828 @default.
- W4377010375 cites W1984991429 @default.
- W4377010375 cites W1985727076 @default.
- W4377010375 cites W1986327962 @default.
- W4377010375 cites W1987081782 @default.
- W4377010375 cites W1988170766 @default.
- W4377010375 cites W1988524372 @default.
- W4377010375 cites W1989679385 @default.
- W4377010375 cites W1990351070 @default.
- W4377010375 cites W1990899386 @default.
- W4377010375 cites W1991255873 @default.
- W4377010375 cites W1991630613 @default.
- W4377010375 cites W1992104196 @default.
- W4377010375 cites W1992696749 @default.
- W4377010375 cites W1994517874 @default.
- W4377010375 cites W1994659764 @default.
- W4377010375 cites W1994737927 @default.
- W4377010375 cites W1994801453 @default.
- W4377010375 cites W1995201708 @default.
- W4377010375 cites W1997286496 @default.
- W4377010375 cites W1998464768 @default.
- W4377010375 cites W1999925297 @default.
- W4377010375 cites W2001881294 @default.
- W4377010375 cites W2002121944 @default.
- W4377010375 cites W2004943901 @default.
- W4377010375 cites W2008187259 @default.
- W4377010375 cites W2008314623 @default.
- W4377010375 cites W2009672068 @default.
- W4377010375 cites W2009987556 @default.
- W4377010375 cites W2010256904 @default.
- W4377010375 cites W2012334457 @default.
- W4377010375 cites W2013095103 @default.
- W4377010375 cites W2013462509 @default.
- W4377010375 cites W2015329065 @default.
- W4377010375 cites W2015351375 @default.
- W4377010375 cites W2015902352 @default.
- W4377010375 cites W2016251348 @default.
- W4377010375 cites W2017267215 @default.
- W4377010375 cites W2017372504 @default.
- W4377010375 cites W2018020399 @default.